期刊
NEUROIMAGE-CLINICAL
卷 35, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2022.103080
关键词
Dementia with Lewy bodies; Alzheimer?s disease; Biomarker; Metabolic brain imaging; FDG PET; Network analysis; Scaled subprofile model; principal component; analysis (SSM; PCA)
类别
资金
- Slovenian Research Agency (ARRS) [P1-0389, J7-2600, J7-3150]
The study aimed to identify a DLB-related pattern (DLBRP) and study its relationship with other metabolic brain patterns, exploring its diagnostic and prognostic value in dementia with Lewy bodies. Results showed that DLBRP shared similarities with ADRP and PDRP, and correlated with cognitive impairment and survival time in patients.
Purpose: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, that shares clinical and metabolic similarities with both Alzheimer's and Parkinson's disease. In this study we aimed to identify a DLB-related pattern (DLBRP), study its relationship with other metabolic brain patterns and explore its diagnostic and prognostic value. Methods: A cohort of 79 participants with DLB, 63 with dementia due to Alzheimer's disease (AD) and 41 normal controls (NCs) and their 2-[18F]FDG PET scans were analysed for identification and validation of DLBRP. Voxelwise correlation and multiple linear regression were used to study the relation between DLBRP and Alzheimer's disease-related pattern (ADRP), Parkinson's disease-related pattern (PDRP) and PD-related cognitive pattern (PDCP). Diagnostic and prognostic value of DLBRP and of modified DLBRP after accounting for ADRP overlap (DLBRP 1 ADRP), were explored. Results: The newly identified DLBRP shared topographic similarities with ADRP (R2 = 24%) and PDRP (R2 = 37%), but not with PDCP. We could accurately discriminate between DLB and NC (AUC = 0.99) based on DLBRP expression, and between DLB and AD (AUC = 0.87) based on DLBRP 1 ADRP expression. DLBRP expression correlated with cognitive impairment, but the correlation was lost after accounting for ADRP overlap. DLBRP and DLBRP 1 ADRP correlated with patients' survival time. Conclusion: DLBRP has proven to be a specific metabolic brain biomarker of DLB, sharing similarities with ADRP and PDRP, but not PDCP. We observed a similar metabolic mechanism underlying cognitive impairment in DLB and AD. DLB-specific metabolic changes were more detrimental for overall survival.
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