期刊
COLLOID JOURNAL
卷 84, 期 2, 页码 162-168出版社
PLEIADES PUBLISHING INC
DOI: 10.1134/S1061933X22020065
关键词
-
eLiposomes, complex nanoemulsion droplets surrounded by a phospholipid bilayer, can deliver compounds with different properties. By employing Langevin-dynamics simulation, it has been found that stable nanoemulsions can be obtained under specific conditions.
At present, hybrid multicompartment carriers for drug delivery have been actively developed; eLiposomes are one such carrier. Due to the complex structure of eLiposomes, which are nanoemulsion droplets surrounded by a phospholipid bilayer, such systems can be used to deliver hydrophilic, hydrophobic, and amphiphilic compounds simultaneously. For the efficient applications, nanoemulsions should be stable in the confined space inside liposomes. In this work, Langevin-dynamics simulation has been employed to study the stability of nanoemulsions with different zeta-potential and various fractions of the dispersed phase. Calculation results have shown that, at low values of the zeta-potential, stable nanoemulsions are formed if a dispersed phase fraction is <= 10 vol %. To produce stable nanoemulsions with higher fractions of the dispersed phase, the absolute value of the zeta-potential of the dispersed phase droplets should be higher than 40 mV. At the same time, the stability of nanoemulsions with both low and high zeta-potentials of the droplets greatly provided by intense Brownian motion of droplets in the internal space of eLiposomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据