期刊
COMPTES RENDUS CHIMIE
卷 18, 期 12, 页码 1320-1327出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2015.09.005
关键词
1,3,4-oxadiazole; 1,2,4-triazole; Indole; Antibacterial activity; Ultrasound irradiation
资金
- Fundamental Research Funds for the Central Universities
- Southwest University for Nationalities [2015NZYQN23]
- Science and Technology Department of Sichuan Province [2012SZ0160, 2012JY0028]
Thirteen novel indole derivatives were efficiently synthesized through ultrasound irradiation by using 4-amino-5-(1H-indol-3-yl)-4H-[1,2,4]triazole-3-thiol (8) and 2-mercapto-5-substituted-1,3,4-oxadiazoles (5a-m). Compared with conventional and microwave methods, yields increased to 82-93%, and reaction times decreased to 15-35 min. The structures of these novel compounds were characterized by spectral data and elemental analysis. Two out of the synthesized compounds (10f and 10l) exhibited excellent activity against Staphylococcus aureus and Escherichia coli, and thus warrant further research. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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