The paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine

MiR-4295, located on chromosome 10q25.2, is a unique miRNA with a wide range of biological functions. miR-4295 is widely expressed in vivo, participating in the biological processes of multiple cancers. Although miR-4295 is dysregulated in various cancers, it has also been found to have the function of inhibiting cancer. At the same time, the expression of miR-4295 is related to prognosis and can be affected by numerous factors connecting to the therapeutic effects of various drugs. This article is to better summarize the role of miR4295 in cancer and review the potential diagnostic, prognostic, and therapeutic value of miR-4295, which may provide insight into subsequent research. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

Automated summary

MiR-4295 is a unique miRNA with a wide range of biological functions involved in various cancers. It can both be dysregulated and also have a tumor-suppressing function, and its expression is associated with prognosis and therapeutic response to drugs.