期刊
CHEMICAL SCIENCE
卷 13, 期 30, 页码 8885-8894出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc02797f
关键词
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资金
- National Natural Science Foundation of China [21901077]
- Natural Science Foundation of Guangdong [2016ZT06C322]
- Research Fund Program of Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices [2019B121203003]
- open project of Key Lab of Organic Optoelectronics & Molecular Engineering
Supramolecular polymer chemistry, integrating noncovalent interactions with polymeric structures, is utilized for living cell engineering, including cell surface engineering and subcellular organelle manipulation, providing a new strategy for living cell engineering.
Supramolecular polymer chemistry, which closely integrates noncovalent interactions with polymeric structures, is a promising toolbox for living cell engineering. Here, we report our recent progress in exploring the applications of cucurbit[7]uril (CB[7])-based supramolecular polymer chemistry for engineering living cells. First, a modular polymer-analogous approach was established to prepare multifunctional polymers that contain CB[7]-based supramolecular recognition motifs. The supramolecular polymeric systems were successfully applied to cell surface engineering and subcellular organelle manipulation. By anchoring polymers on the cell membranes, cell-cell interactions were established by CB[7]-based host-guest recognition, which further facilitated heterogeneous cell fusion. In addition to cell surface engineering, placing the multifunctional polymers on specific subcellular organelles, including the mitochondria and endoplasmic reticulum, has led to enhanced physical contact between subcellular organelles. It is highly anticipated that the CB[7]-based supramolecular polymer chemistry will provide a new strategy for living cell engineering to advance the development of cell-based therapeutic materials.
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