One-pot synthesis of 4-substituted 2-fluoroalkyloxazoles from NH-1,2,3-triazoles and fluoroalkylated acid anhydrides

An efficient one-pot method for the synthesis of 2-fluoroalkyloxazoles from 4-substituted NH-1,2,3-triazoles, fluorinated anhydrides and triethylamine was developed. Structurally diverse fluoroalkylated oxazoles (R-F = CF3, C2F5, CF2Cl, CF2H) were prepared in high yields from readily available starting reagents in mild conditions. An alternative direct method for fluoroalkylated oxazole synthesis from electron-rich NH-triazoles using acetonitrile as the solvent was described.

Automated summary

An efficient one-pot method has been developed for the synthesis of 2-fluoroalkyloxazoles. This method offers a mild and high-yielding approach to prepare structurally diverse fluoroalkylated oxazoles from readily available starting reagents. Furthermore, an alternative direct method using acetonitrile as the solvent has been described for the synthesis of fluoroalkylated oxazoles from electron-rich NH-triazoles.