Febrile children with comorbidities at the emergency department - a multicentre observational study

Article Multidisciplinary Sciences

Characteristics of pediatric emergency department frequent visitors and their risk of a return visit: A large observational study using electronic health record data

Sanne E. W. Vrijlandt et al.

Summary: Pediatric emergency department frequent visitors are a small group of children who account for a large proportion of total visits. They are typically younger, have chronic diseases, and present more often with infectious conditions.

PLOS ONE (2022)

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Article Medicine, General & Internal

Characteristics and management of adolescents attending the ED with fever: a prospective multicentre study

Dorine Borensztajn et al.

Summary: This study focuses on febrile adolescents and describes their characteristics and management in the emergency department. The results show that although younger children visit the emergency department more frequently, adolescents are more likely to be diagnosed with serious bacterial infections and sepsis/meningitis.

BMJ OPEN (2022)

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Article Pediatrics

Improving triage for children with comorbidity using the ED-PEWS: an observational study

Joany M. Zachariasse et al.

Summary: The Emergency Department-Pediatric Early Warning Score (ED-PEWS) has a similar performance in triaging children with and without comorbidity, and adding ED-PEWS to the Manchester Triage System (MTS) improves triage for children with comorbidity, except in settings with few high-urgency patients.

ARCHIVES OF DISEASE IN CHILDHOOD (2022)

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Article Pediatrics

Shock Index in the early assessment of febrile children at the emergency department: a prospective multicentre study

Nienke N. Hagedoorn et al.

Summary: The study found that a high Shock Index is associated with serious illness in febrile children, but its value for ruling out serious illness is inadequate, suggesting that the Shock Index is not suitable as a screening tool for all febrile children in the emergency department.

ARCHIVES OF DISEASE IN CHILDHOOD (2022)

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Article Medicine, General & Internal

Identifying children with medical complexity in administrative datasets in a Canadian context: study protocol

Holly McCulloch et al.

Summary: This study aims to understand the population of children with medical complexity in the Canadian Maritimes and evaluate disparities in healthcare resource allocation and utilization. The study will be conducted in three phases, including identifying the children, estimating the prevalence, and describing healthcare utilization patterns.

BMJ OPEN (2022)

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Article Pediatrics

Prevalence of Children With Medical Complexity and Associations With Health Care Utilization and In-Hospital Mortality

JoAnna K. Leyenaar et al.

Summary: This study used open-source algorithms to estimate the prevalence of children with medical complexity (CMC) and found that these children have high healthcare utilization and in-hospital mortality rates. These findings are important for research, program development, and policy-making for CMC.

JAMA PEDIATRICS (2022)

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Article Pediatrics

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019

Benedetta Armocida et al.

Summary: The burden of non-communicable diseases (NCDs) has decreased among adolescents in the EU between 1990 and 2019, but there is a concerning trend of increased years of life lost (YLL) and disability-adjusted life years (DALY) due to mental disorders. The differences by sex, age group, and EU Member States highlight the importance of preventive interventions and scaling up adolescent-responsive healthcare systems.

LANCET CHILD & ADOLESCENT HEALTH (2022)

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Article Pediatrics

Development and validation of a prediction model for invasive bacterial infections in febrile children at European Emergency Departments: MOFICHE, a prospective observational study

Nienke N. Hagedoorn et al.

Summary: A clinical prediction model was developed and cross-validated to identify invasive bacterial infections in febrile children, showing potential to reduce unnecessary antibiotic treatment. The model performed well in ruling out IBI and could benefit from the use of sensitive biomarkers to improve identification in patients at intermediate risk.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

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Review Medicine, General & Internal

Characteristics of frequently attending children in hospital emergency departments: a systematic review

Geva Greenfield et al.

Summary: The review included 21 studies with a total of 6,513,627 children. Children who were frequent users of EDs were more likely to be under 5 years old and have frequent use of primary care services, with common diagnoses being infections and gastroenteritis.

BMJ OPEN (2021)

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Article Pediatrics

A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies

Ruud G. Nijman et al.

Summary: The biomarkers of bacterial infection were closely associated with diagnostic categories using the new PERFORM classification system in five independent cohorts. Our proposed algorithm provides a novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies.

FRONTIERS IN PEDIATRICS (2021)

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Article Pediatrics

Predictors of serious bacterial infections using serum biomarkers in an infant population aged 0 to 90 days: a prospective cohort study

Serena Su Ying Chang et al.

Summary: In young febrile infants, C-reactive protein (CRP) is the best discriminatory biomarker for serious bacterial infections (SBI). White blood cell count (WBC), absolute neutrophil ratio (ANC), and neutrophil to lymphocyte ratio (NLR) in combination also show potential diagnostic utility in this population.

BMJ PAEDIATRICS OPEN (2021)

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Article Health Care Sciences & Services

A NICE combination for predicting hospitalisation at the Emergency Department: a European multicentre observational study of febrile children

Dorine M. Borensztajn et al.

Summary: The study developed and validated a prediction model for early identification of febrile children at high risk of hospitalization, using patient characteristics and NICE alarming signs available at triage, to improve ED flow. The model performed well for both rule-in and rule-out thresholds, showing good discriminative values and validation in a separate dataset. Funding was provided by the European Union, NIHR, and NHS.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Article Pediatrics