期刊
LAB ON A CHIP
卷 22, 期 15, 页码 2886-2901出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2lc00200k
关键词
-
类别
资金
- German Research Foundation [SCHM 2365/17-1]
- Ministry of Science and Higher Education of the Russian Federation
Acoustic tweezers provide a noninvasive, contactless method for precise manipulation of micro objects, including biological cells. This study reveals the correlation between acoustic fields, acoustophoretic motion and heating effects, and demonstrates three-dimensional particle patterning and rapid heating.
Acoustic tweezers facilitate a noninvasive, contactless, and label-free method for the precise manipulation of micro objects, including biological cells. Although cells are exposed to mechanical and thermal stress, acoustic tweezers are usually considered as biocompatible. Here, we present a holistic experimental approach to reveal the correlation between acoustic fields, acoustophoretic motion and heating effects of particles induced by an acoustic tweezer setup. The system is based on surface acoustic waves and was characterized by applying laser Doppler vibrometry, astigmatism particle tracking velocimetry and luminescence lifetime imaging. In situ measurements with high spatial and temporal resolution reveal a three-dimensional particle patterning coinciding with the experimentally assisted numerical result of the acoustic radiation force distribution. In addition, a considerable and rapid heating up to 55 degrees C depending on specific parameters was observed. Although these temperatures may be harmful to living cells, counter-measures can be found as the time scales of patterning and heating are shown to be different.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据