期刊
NPJ FLEXIBLE ELECTRONICS
卷 6, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41528-022-00192-6
关键词
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资金
- Joint Fund of the Ministry of Education for Equipment Pre-research [8091B022142]
- Shenzhen Stability Support Plan [20200806163622001]
- Shenzhen Overseas Talent Program
- Shenzhen Key Laboratory for Nano-Biosensing Technology [ZDSYS20210112161400001]
This study presents a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition of targeted biomarkers in sweat. Compared to conventional wearable SERS platforms, the microfluidic system allows controlled and high temporal-resolution analysis.
Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring. Here, we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea, lactate, and pH in sweat. A miniature, thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering (SERS) activity is designed and integrated into a microfluidics platform. Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat, the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion, providing refreshable SERS analysis. We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers. This study integrates epidermal microfluidics with portable SERS molecular recognition, presenting a controllable, handy, and dynamical biofluid sensing system for personalized medicine.
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