Highly-selective synthesis of functionalized spirobenzofuranones and diketones

A convenient and atom-economical rhodium(iii)-catalyzed highly-selective hydroacylation for the synthesis of spirobenzofuranones and diketones has been successfully developed. Ortho-hydroxyl-group-assisted aldehyde C-H cascade [4 + 1] annulation makes the formation of spiro compounds more efficient.

Automated summary

A convenient and atom-economical rhodium(iii)-catalyzed hydroacylation reaction has been developed for the synthesis of spirobenzofuranones and diketones. The use of ortho-hydroxyl-group-assisted aldehyde C-H cascade [4 + 1] annulation enhances the efficiency of spiro compound formation.