Revealing the mystery of persistent smell loss in long COVID patients

COVID-19 is hopefully approaching its end in many countries as herd immunity develops and weaker strains of SARS-CoV-2 dominate. However, a new concern occurs over the long-term effects of COVID-19, collectively called ???Long COVID???, as some symptoms of the nervous system last even after patients recover from COVID-19. This review focuses on studies of anosmia, i.e., impairment of smell, which is the most common sensory defect during the disease course and is caused by olfactory dysfunctions. It remains mysterious how the olfactory functions are affected since the virus can???t invade olfactory receptor neurons. We describe several leading hypotheses about the mystery in hope to provide insights into the pathophysiology and treatment strategies for anosmia.

Automated summary

COVID-19's long-term effects, known as "Long COVID," raise concerns about persistent symptoms of the nervous system, such as anosmia. The exact mechanisms behind olfactory dysfunctions caused by COVID-19 remain unknown since the virus cannot invade olfactory receptor neurons. This review explores leading hypotheses to gain insights into the pathophysiology and treatment strategies for anosmia.