期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 32, 页码 6394-6399出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob01084d
关键词
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资金
- National Natural Science Foundation of China [21962004, 22161003]
- Jiangxi Provincial Department of Science and Technology [20192BAB203004]
- Fundamental Research Funds for Gannan Medical University [QD201810, TD2021YX05]
Cationic iridium complexes were demonstrated to catalyze the transfer hydrogenation of oximes, providing access to N-alkoxy amines and hydroxylamines. The reaction rate was accelerated by trifluoroacetic acid. The practical application of this method was demonstrated by the synthesis of a fungicide in high yields, and the asymmetric synthesis of chiral N-alkoxy amines showed potential for further development.
Cationic iridium (Ir) complexes were found to catalyze the transfer hydrogenation of oximes to access N-alkoxy amines and hydroxylamines, and the reaction was accelerated by trifluoroacetic acid. The practical application of this protocol was demonstrated by a gram-scale transformation and two-step synthesis of the fungicide furmecyclox (BAS 389F) in overall yields of 92 and 85%, respectively. An asymmetric protocol using chiral Ir complexes to afford chiral N-alkoxy amines was demonstrated, but the low yields/ee obtained indicated that further development was required.
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