Silver-Catalyzed Synthesis of CF3-Substituted 2-Imidazolines

The silver salt catalyzed [3+2] cycloaddition reaction of trifluoromethylated N-acylhydrazones and ethyl isocyanoacetate was investigated. The reaction proceeds quickly to produce a series of trifluoromethylated 2-imidazoline compounds in high yields with excellent stereoselectivity, which provides a novel and efficient method for the synthesis of trifluoromethylated 2-imidazoline compounds.

Automated summary

The silver salt-catalyzed [3+2] cycloaddition reaction of trifluoromethylated N-acylhydrazones and ethyl isocyanoacetate was investigated, which efficiently produced a series of trifluoromethylated 2-imidazoline compounds in high yields with excellent stereoselectivity, providing a novel and efficient method for their synthesis.