4.7 Article

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR

期刊

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 11, 页码 4560-4577

出版社

IVYSPRING INT PUBL
DOI: 10.7150/ijbs.69933

关键词

Key words; gastric cancer; urokinase-type plasminogen activator receptor; transcription Factor 7 Like 2; transcription; anoikis

资金

  1. National Natural Science Foundation of China [81670594, 81470791, 81376597, 81802269]
  2. Major Science and Technology Project of Gansu Province [19ZD2WA001]
  3. Natural Science Foundation of Gansu Province [1606 RJIA328, 20JR5RA352, 20JR10RA686, 21JR7RA386]
  4. Gansu Province Higher Education Innovation Ability Improvement Project [2019B-009, 2020B-009]

向作者/读者索取更多资源

This study identifies urokinase-type plasminogen activator receptor (PLAUR) and transcription Factor 7 Like 2 (TCF7L2) as important factors promoting gastric cancer (GC) metastasis. TCF7L2 regulates PLAUR expression and is an independent risk factor for poor prognosis in GC patients. Therefore, TCF7L2 and PLAUR may be potential targets for therapeutic strategies against GC metastasis.
Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant metastasis is a critical factor in the prognosis of patients with GC. Understanding the mechanism of GC metastasis will help improve patient prognosis. Studies have confirmed that urokinase-type plasminogen activator receptor (PLAUR) promotes GC metastasis; however, its relationship with anoikis resistance and associated mechanisms remains unclear. In this study, we demonstrated that PLAUR promotes the anoikis resistance and metastasis of GC cells and identified transcription Factor 7 Like 2 (TCF7L2) as an important transcriptional regulator of PLAUR. We also revealed that TCF7L2 is highly expressed in GC and promotes the anoikis resistance and metastasis of GC cells. Moreover, we found that TCF7L2 transcription activates PLAUR. Finally, we confirmed that TCF7L2 is an independent risk factor for poor prognosis of patients with GC. Our results show that TCF7L2 and PLAUR are candidate targets for developing therapeutic strategies for GC metastasis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据