Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones

A Cu-catalyzed 5-endo-selective trifluoromethylcarbocyclization of ynones is developed for the concise synthesis of trifluoromethylated cyclopentenones. The pivotal roles of carbonyl groups are well illustrated by experiments and density functional theory calculations.

Automated summary

A Cu-catalyzed 5-endo-selective trifluoromethylcarbocyclization of ynones has been developed for the concise synthesis of trifluoromethylated cyclopentenones. The pivotal roles of carbonyl groups in the reaction have been well illustrated by experiments and density functional theory calculations.