期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 30, 页码 5826-5834出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb01005d
关键词
-
资金
- National Key R&D Program of China [2018YFC1105100]
- National Natural Science Foundation of China [217711600, 22077114]
This study found that succinic acid can significantly promote the mineralization of collagen fibers and accelerate the process of mineralization by interacting with collagen molecules. Demineralized dentin pretreated with succinic acid can be completely remineralized in a shorter time and shows improved mechanical properties.
Biomineralization of collagen fibers is regulated by non-collagenous proteins and small biomolecules, which are essential in bone and teeth formation. In particular, small biomolecules such as succinic acid (SA) exist at a high level in hard tissues, but their role is yet unclear. Here, our work demonstrated that SA could significantly promote intrafibrillar mineralization in two- and three-dimensional collagen models, where the relative mineralization rate was 16 times faster than the control group. Furthermore, the FTIR spectra and isothermal experimental results showed that collagen molecules could interact with SA via a hydrogen bond and that the interaction energy was about 4.35 kJ mol(-1). As expected, the SA-pretreated demineralized dentin obtained full remineralization within two days, whereas it took more than four days in the control group, and their mechanical properties were considerably enhanced compared with those of the demineralized one. The possible mechanism of the promotion effect of SA was ultimately illustrated, with SA modification strengthening the capacity of the collagen matrix to attract more calcium ions, which might create a higher local concentration that could accelerate the mineralization of collagen fibers. These findings not only advance the understanding of the vital role of small biomolecules in collagen biomineralization but also facilitate the development of an effective strategy to repair hard tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据