期刊
OPEN CHEMISTRY
卷 20, 期 1, 页码 703-707出版社
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/chem-2022-0189
关键词
ester; l-menthol; phenibut; terpenoid; anticonvulsant activity; Steglich esterification
Phenibut ester was synthesized using a coupling reagent and a catalyst, and its purity was assessed using various spectroscopic methods. The anticonvulsant profile of phenibut ester was examined in different seizure models.
Ester based on l-menthol and phenibut - (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride was obtained in 78% yield using N,N '-dicyclohexylcarbodiimide as a coupling reagent along with catalytic amount of 4-dimethylaminopyridine. The obtained product was characterized by FT-IR, fast-atom bombardment-mass spectrometry along with H-1-NMR and C-13-NMR spectral analysis; the purity was assessed using high-performance liquid chromatography. Phenibut ester has been examined on the models of chemically- and electrically-induced seizures for potential anticonvulsant profile.
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