Rationally designed Ru(ii) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer

Herein, we construct a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(ii) metallacycles in biomedicine.

Automated summary

In this study, we synthesized a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which showed higher anticancer activity and better cancer-cell selectivity compared to cisplatin. The antitumor mechanism was attributed to the activation of caspase 3/7 and subsequent apoptosis. These findings suggest new potential applications of Ru(ii) metallacycles in biomedicine.