期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 32, 页码 6363-6367出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00839d
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资金
- CSIR
- DST [EMR/2017/0002413]
A cascade reaction of enynones with enaminones via carbene insertion and aryl migration is reported in this study, which efficiently constructs distinctive multisubstituted furans with an all-carbon quaternary center. The protocol can be extended to synthesize furano-pyrrole bis-heterocycles in the same pot. The heterogeneity of this reaction was demonstrated by generating divergent chemical space under relatively mild reaction conditions.
A synthetic strategy that efficiently constructs complex molecular diversity in a few steps will always be embraced by organic chemists. Here, we report a cascade reaction of enynones with enaminones via carbene insertion and aryl migration to engineer distinctive multisubstituted furans with an all-carbon quaternary center, and could extend the protocol in the same pot towards furano-pyrrole bis-heterocycles. Heterogeneity of this protocol was proved with the upshot of divergent chemical space under a relatively mild reaction environment.
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