期刊
FOOD & FUNCTION
卷 13, 期 16, 页码 8643-8651出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2fo01719a
关键词
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资金
- National Natural Science Foundation of China [31760251]
- Basic Research Program of the Guizhou Provincial Department of Science and Technology (Natural Science) [qiankehejichu-ZK [2022] yiban599]
- Program for Excellent Young Talents of Zunyi Medical University [18zy-006]
This study found that Lonicera japonica polysaccharide can inhibit the cue-induced reinstatement of alcohol addiction memory, mitigate hippocampal neuronal damage, and reduce abnormal enhancement of alcohol-induced addiction memory. Additionally, VPS34 was identified as a potential target for modulating alcohol cravings.
Alcohol is one of the most commonly used addictive substances. Addiction memory is a necessary part of the mechanism underlying drug addiction. Lonicera japonica and its extract can mitigate organ damage caused by alcohol. In this study, Lonicera japonica polysaccharide (LJP) was extracted, and its effect on alcohol addiction memory was investigated. LJP inhibited the cue-induced reinstatement of conditioned place preference and elevated Tuj1 and DCX levels in the hippocampus to suppress neuronal damage. LJP also reduced the hippocampal glutamate (Glu) levels, alcohol-induced abnormal enhancement of the addiction memory, and decreased VPS34 phosphorylation and hyper activation of autophagy pathways in the hippocampus of alcohol-dependent mice. Our results suggest that LJP is a potential functional food to treat or ameliorate alcohol-induced addiction and that VPS34 is a potential target for modulating alcohol cravings.
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