期刊
ACS ORGANIC & INORGANIC AU
卷 2, 期 4, 页码 289-305出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsorginorgau.2c00009
关键词
asymmetric organocatalysis; epoxides; desymmetrization; kinetic resolution; Meinwald rearrangement; one-pot reaction
资金
- University of Salerno
- MUR
- European Union
Optically pure epoxides are valuable products and key intermediates, useful in various fields such as pharmaceuticals, agrochemicals, natural product synthesis, and materials science. The predictable ring-opening process allows for selective installation of functional groups at desired carbon atoms. Asymmetric organocatalysis has provided a convenient tool for the preparation and elaboration of these compounds.
Optically pure epoxides are recognized as highly valuable products and key intermediates, useful in different areas from pharmaceutical and agrochemical industries to natural product synthesis and materials science. The predictable fate of the ringopening process, in terms of stereoselectivity and often of regioselectivity, enables useful functional groups to be installed at vicinal carbon atoms in a desired manner. In this way, products of widespread utility either for synthetic applications or as final products can be obtained. The advent of asymmetric organocatalysis provided a new convenient tool, not only for their preparation but also for the elaboration of this class of heterocycles. In this review, we focus on recent developments of stereoselective organocatalytic ringopening reactions of meso-epoxides, kinetic resolution of racemic epoxides, and Meinwald-type rearrangement. Examples of asymmetric organocatalytic processes toward specific synthetic targets, which include ring opening of an epoxide intermediate, are also illustrated.
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