期刊
JOURNAL OF CANCER
卷 13, 期 9, 页码 2933-2944出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.71401
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资金
- National Nature Science Foundation of China [82103032]
- Medical Research Grant of Jiangsu Commission of Health [M2020010]
- Health Science and Technology Development Fund of Nanjing [YKK21224]
- Science Foundation of Jiangsu Health vocational college [JKC201948]
- Science and Technology Development Fund of Nanjing Medical University [NMUB2019235]
- Kangda College of Nanjing Medical University [KD2020KYJJZD006, KD2021KYJJZD026]
miR-211 shows significant expression variations in various cancers and may serve as a potential prognostic marker, regulating multiple biological processes in cancer.
MircoRNA (miRNA), which are a group of small, and highly conserved non-coding RNA consisting of 18-25 nucleotides, can modulate gene expression at post-transcriptional level, through complementary binding to the 3'-untranslated region (3'-UTR) of numerous target genes. Emerging evidence indicates that miRNAs play critical roles in tumorigenesis and progression of cancer. Among them, miR-211 has been extensively studied in multiple cancers. The expression of miR-211 significantly varies with cancer types and may be used as a potential prognostic marker for cancer. MiR-211 can regulate multiple biological processes in cancer, including proliferation, apoptosis, metastasis and drug resistance. Additionally, several factors may contribute to the dysregulation of miR-211 in cancer. Consequently, this review aims to discuss the novel findings that highlight latent value of miR-211 in the prognosis assessment and treatment of cancer.
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