Asymmetric cross Rauhut-Currier reactions of vinyl ketones with carbonyl para-quinone methides via phosphine catalysis

Novel cross Rauhut-Currier reactions involving chiral phosphine catalysis between vinyl ketones and terminal-carbonyl-substituted para-quinone methides have been presented. This reaction approach showed broad substrate scope compatibility and moderate-to-excellent enantioselectivity control. The multifunctional products could be easily transformed to important and useful skeletons. Moreover, natural-product and drug derivatives were well tolerated in this methodology, exhibiting the promising applications of this reaction approach.

Automated summary

The novel chiral phosphine-catalyzed cross Rauhut-Currier reactions provide a versatile approach for the synthesis of multifunctional compounds. The reaction exhibits broad substrate scope and moderate-to-excellent enantioselectivity control. It also shows promising applications in the synthesis of drug and useful compounds due to its tolerance towards natural product and drug derivatives.