期刊
EMERGING INFECTIOUS DISEASES
卷 28, 期 7, 页码 1403-1409出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2807.212273
关键词
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资金
- Ministry of Health, Welfare and Sport of the Netherlands
Early detection and treatment of chronic Q fever through screening program can prevent potentially life-threatening complications. In the Netherlands, 10 years after a large Q fever outbreak, targeted screening in general practitioner practices still detected patients with chronic Q fever and is estimated to be cost-effective.
Early detection of and treatment for chronic Q fever might prevent potentially life-threatening complications. We performed a chronic Q fever screening program in general practitioner practices in the Netherlands 10 years after a large Q fever outbreak. Thirteen general practitioner practices located in outbreak areas selected 3,419 patients who had specific underlying medical conditions, of whom 1,642 (48%) participated. Immunofluorescence assay of serum showed that 289 (18%) of 1,642 participants had a previous Coxiella burnetii infection (IgG II titer >= 1:64), and 9 patients were suspected of having chronic Q fever (IgG I y titer >= 1:512). After medical evaluation, 4 of those patients received a chronic Q fever diagnosis. The cost of screening was higher than estimated earlier, but the program was still cost-effective in certain high risk groups. Years after a large Q fever outbreak, targeted screening still detected patients with chronic Q fever and is estimated to be cost-effective.
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