期刊
MEDICINA-LITHUANIA
卷 58, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/medicina58070926
关键词
intratumoral budding (ITB); colorectal carcinoma (CRC); tumor microenvironment (TME); desmoplastic reaction (DR); Klintrup-Makinen (KM) grade; tumor-stroma ratio (TSR); pretreatment biopsy samples (PBS)
资金
- Catholic Medical Center (CMC) of Korea Research Foundation [5-2017-B0001-00240]
- Catholic University of Korea, Uijeongbu St. Mary's Hospital Clinical Research Laboratory Foundation [5-2013-B0001-00157]
This study examined the prognostic factors and neoadjuvant therapy effect prediction in patients with advanced or unresectable CRC, finding that high-grade ITB may be associated with unfavorable prognosis, while immature DR, TSR, and KM grade cannot predict prognosis or therapy response.
Background and Objectives: The prediction of the prognosis and effect of neoadjuvant therapy is vital for patients with advanced or unresectable colorectal carcinoma (CRC). Materials and Methods: We investigated several tumor microenvironment factors, such as intratumoral budding (ITB), desmoplastic reaction (DR), and Klintrup-Makinen (KM) inflammation grade, and the tumor-stroma ratio (TSR) in pretreatment biopsy samples (PBSs) collected from patients with advanced or unresectable CRC. A total of 85 patients with 74 rectal carcinomas and 11 colon cancers treated at our hospital were enrolled; 66 patients had curative surgery and 19 patients received palliative treatment. Results: High-grade ITB was associated with recurrence (p = 0.002), death (p = 0.034), and cancer-specific death (p = 0.034). Immature DR was associated with a higher grade of clinical tumor-node-metastasis stage (cTNM) (p = 0.045), cN category (p = 0.045), and cM category (p = 0.046). The KM grade and TSR were not related to any clinicopathological factors. High-grade ITB had a significant relationship with tumor regression in patients who received curative surgery (p = 0.049). Conclusions: High-grade ITB in PBSs is a potential unfavorable prognostic factor for patients with advanced CRC. Immature DR, TSR, and KM grade could not predict prognosis or therapy response in PBSs.
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