期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 6, 页码 2292-2303出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.69411
关键词
ubiquitination; E3 ubiquitin ligase; deubiquitinase; metastasis
资金
- China's National Natural Science Foundation [81972837]
This review summarizes the regulatory role of ubiquitination in tumor metastasis, particularly focusing on the important roles of E3 ubiquitin ligases and deubiquitinases, and discusses the relationship between ubiquitination components and tumor progression.
Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.
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