Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of physiological systems is associated with pathophysiological disorders. Here, we review the current understanding of the molecular mecha-nisms contributing to the known circadian rhythms in physiological function. This article focuses on what is known in humans, along with discoveries made with cell and rodent models. In particular, the impact of circadian clock components in metabolic, cardiovascular, endocrine, musculoskele-tal, immune, and central nervous systems are discussed. ?? 2022 American Physiological Society. Compr Physiol 12:2769-2798, 2022.

Automated summary

This article reviews the impact of circadian rhythms on physiological function in humans and discusses findings from cell and rodent models.