Association between TGF-β gene polymorphism and myopia: A systematic review and meta-analysis

Introduction: The present study was conducted to determine the association of transforming growth factor-beta (TGF-beta) gene polymorphism and myopia. Method: Four hundred twelve articles were identified, of which 11 articles with 5213 participants in 4 countries were included in the final analysis. Review Manager software (RevMan, version 5.4) was used for data analysis. Result: Odds ratio (OR) value of TGF-beta 1 rs1800469 is 1.33 (95% confidence interval [CI] = 1.15-1.54) in the allelic model; in the dominant model is 1.76 (95% CI = 1.16-2.67); in homozygous model is 5.98 (95% CI = 4.31-8.06). OR value of TGF-beta 1 rs4803455 is 0.62 (95% CI = 0.43-0.88) in recessive model. TGF-beta 2 is not associated with myopia. Relevant study on TGF-beta 3 is scarce. Conclusion: Our systematic review and meta-analysis found that TGF-beta 1 rs4803455 and rs1800469 were correlated with myopia.

Automated summary

This study found through a systematic review and meta-analysis that TGF-beta1 rs4803455 and rs1800469 are associated with myopia, while TGF-beta2 is not, and there is limited research on TGF-beta3 and myopia.