Enantioselective redox gold catalysis

Au(I)/Au(III) redox catalysis, also known as redox gold catalysis, has evolved as a new technique in the past decade, opening up possibilities for the cross-coupling and 1,2-difunctioalization reactions of C-C multiple bonds that were previously inaccessible with gold(I) or gold(III) catalysis. However, the enantioselective Au(I)/Au(III) redox catalysis was missing until recently. The research group of Patil and Shi independently developed new hemilabile chiral (P,N)-ligands to achieve enantioselective redox gold catalysis for the first time.

Automated summary

Au(I)/Au(III) redox catalysis, a new technique developed in the past decade, enables cross-coupling and 1,2-difunctionalization reactions of C-C multiple bonds. However, achieving enantioselectivity has been a challenge. Recently, the research group of Patil and Shi achieved enantioselective redox gold catalysis by developing novel chiral ligands.