4.7 Article

Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pediatrics

The COVID-19 pandemic and its potential enduring impact on children

Margaret Irwin et al.

Summary: This review examines the various ways in which children and adolescents are affected by the COVID-19 pandemic, including physical, psychological, educational, developmental, behavioral, and social aspects. It emphasizes the need for pediatricians to be aware of and address these impacts in order to support the well-being and development of children. Further research is necessary to understand and evaluate the long-term consequences and challenges posed by COVID-19.

CURRENT OPINION IN PEDIATRICS (2022)

Review Biochemistry & Molecular Biology

Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones

Ana Paco et al.

Summary: This review summarizes the current knowledge regarding the therapeutic potential of sesquiterpene lactones in immune and inflammatory activities, discussing the action mechanisms, bioaccessibility, and molecular structure-activity relationships in different cellular models and in vivo studies. Additionally, the impact of plant metabolic engineering and extraction methodologies on biological activity enhancement is presented.

MOLECULES (2022)

Article Biochemical Research Methods

Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2

Kubra Dogan et al.

Summary: The study analyzed the artemisinin content in Artemisia annua plants grown in Turkey using different extraction methods and investigated its biological activity against SARS-CoV-2. Results showed significant inhibition of 3CL protease activity by artemisinin, but no effect on Spike/ACE-2 binding. In addition, artemisinin demonstrated immunosuppressive effects on TNF-alpha production in a dose-dependent manner.

PHYTOCHEMICAL ANALYSIS (2022)

Review Plant Sciences

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Karim Farmanpour-Kalalagh et al.

Summary: Artemisinin is a natural compound derived from Artemisia annua with potential applications in treating malaria, viral infections, inflammation, and certain cancers. Recent studies indicate its positive effects in combating COVID-19. However, increasing its production through synthesis or biotechnological engineering is necessary for implementing its various potential uses.

FRONTIERS IN PLANT SCIENCE (2022)

Review Chemistry, Multidisciplinary

Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One Stone

Haihai Jiang et al.

Summary: This review describes the structural and functional features of PLpro of SARS-CoV-2 and the latest developments in searching for PLpro inhibitors.

FRONTIERS IN CHEMISTRY (2022)

Article Chemistry, Medicinal

Antiviral Effects of Artemisinin and Its Derivatives against SARS-CoV-2 Main Protease: Computational Evidences and Interactions with ACE2 Allelic Variants

Riadh Badraoui et al.

Summary: This study evaluates the interaction between artemisinin and its derivatives with the SARS-CoV-2 main protease, revealing their potential antiviral activity against COVID-19. The findings suggest that artemisinin may inhibit the activity of the main protease and provide insights into the ethnopharmacological use of this herb.

PHARMACEUTICALS (2022)

Article Biochemistry & Molecular Biology

Identifying structural-functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation

Priyashi Rao et al.

Summary: The non-structural protein (nsp)-3 of SARS-CoV2, also known as papain-like protease (PLpro), is considered as an essential target protein for inhibiting the replication of the virus. Studies have identified GRL0617 and Fonsecin as potent inhibitors for PLpro, which may help in boosting the immune response.

MOLECULAR DIVERSITY (2022)

Article Chemistry, Medicinal

Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening

Li-chuan Zhang et al.

Summary: In this study, three compounds were identified that have the potential to inhibit the main protease and papain-like protease of SARS-CoV-2. These compounds can be further investigated as potential lead compounds for SARS-CoV-2 inhibitors.

FUTURE MEDICINAL CHEMISTRY (2022)

Article Chemistry, Medicinal

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease

Haozhou Tan et al.

Summary: This article summarizes the significant progress in structure-based design and high-throughput screening of SARS-CoV-2 papain-like protease (PLpro) inhibitors since the beginning of the pandemic. Encouraging achievements include the development of non-covalent and covalent inhibitors with favorable pharmacokinetic properties. The article also identifies knowledge gaps that need to be addressed to advance PLpro inhibitors to clinical application.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Microbiology

Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in vitro Studies

Rajkumar Kulandaisamy et al.

Summary: In this study, potential inhibitors of SARS-CoV-2 PLpro were identified through virtual screening and their interactions with the enzyme were confirmed through docking and molecular dynamics simulation studies. The high structural conservation between SCoV-2 and HCoV-229E PLpro suggests the suitability of HCoV-229E as a surrogate for drug discovery studies. Moreover, Mefloquine, which was effective against HCoV-229E, was found to have antiviral activity against SCoV-2.

FRONTIERS IN MICROBIOLOGY (2022)

Review Chemistry, Multidisciplinary

Inhibitors of SARS-CoV-2 PLpro

Dale J. Calleja et al.

Summary: The emergence of SARS-CoV-2 and the COVID-19 pandemic have emphasized the importance of urgent collaboration and building on existing research for rapid vaccine development. However, even highly vaccinated countries still face surges in cases and hospitalizations. Therefore, the development of antiviral treatments remains a top priority to prevent hospitalization and death, and ultimately end the pandemic caused by SARS-CoV-2. The focus of this review is on the essential papain-like protease (PLpro) domain within the nsp3 protein of SARS-CoV-2, which plays a crucial role in viral processing and immune response inhibition. Small molecule inhibitors of PLpro have shown promising results in reducing viral loads, making PLpro an excellent target for next generation antivirals. The review discusses ongoing efforts in designing PLpro inhibitors and optimizing existing compounds for more effective treatment options.

FRONTIERS IN CHEMISTRY (2022)

Article Biology

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

Anoop Narayanan et al.

Summary: In this study, a screening strategy for antiviral drugs against SARS-CoV-2 was developed, which involves in-cell protease assay, antiviral and biochemical activity assessments, as well as structural determinations. Several protease inhibitors with low cytotoxicity were identified and their mechanisms of action were examined.

COMMUNICATIONS BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds

Io Antonopoulou et al.

Summary: The emergence of SARS-CoV-2 has led to a long pandemic with significant global impact. Developing inhibitors against the main protease offers promising solutions to combat the virus and potential mutations.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

Article Medicine, Research & Experimental

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Vitor Borges et al.

Summary: Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented in collaboration with over 50 laboratories distributed nationwide. The study detected at least 277 independent introductions of SARS-CoV-2, mostly from European countries, highlighting the importance of early measures in minimizing the spread of the virus.

COMMUNICATIONS MEDICINE (2022)

Review Biochemistry & Molecular Biology

Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds

Io Antonopoulou et al.

Summary: The emergence of SARS-CoV-2 has resulted in a global pandemic, and it is crucial to develop further methods to combat the infection and inhibit viral mutations. The main protease (Mpro) of the virus is an attractive target for inhibitors development. This article aims to present the research results of Mpro inhibitors to date and provide a basis for effective solutions against SARS-CoV-2 and future outbreaks. Evaluating the functionality of these compounds in in vitro and in vivo assays.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

Article Chemistry, Medicinal

Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study

Izabela Nawrot-Hadzik et al.

Summary: The study investigated the potential antiviral activity of compounds from Reynoutria japonica against SARS-CoV-2, with vanicoside A and vanicoside B showing good inhibitory effects, while the butanol fractions exhibited the strongest inhibition. These findings provide insights into the beneficial effects of Reynoutria japonica on COVID-19 and identify promising compounds for further research.

PHARMACEUTICALS (2021)

Article Chemistry, Medicinal

Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens

Suvi T. Hakkinen et al.

Summary: Chicory contains bioactive compounds with antimicrobial, antifungal, and antibiofilm activities. Supercritical fluid extracts showed the highest bioactivity, inhibiting drug-resistant bacteria and fungi. There is potential for the development of novel antibacterial and antifungal preparations from chicory extracts.

PHARMACEUTICALS (2021)

Article Chemistry, Physical

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study

Nayim Sepay et al.

Summary: Traditional medicines containing natural products have shown potential in fighting against the COVID-19 virus, with certain natural products identified as potential candidates for drug development.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Chemistry, Applied

Chicory (Cichorium intybus L.) as a food ingredient - Nutritional composition, bioactivity, safety, and health claims: A review

Jelena Perovic et al.

Summary: Chicory is a globally cultivated perennial herb used in animal feed and food production, such as salads, teas, coffee supplements, and inulin production. Compounds in chicory, like polyphenols and inulin, are considered potential carriers of food functionality and have wide applications in the food industry.

FOOD CHEMISTRY (2021)

Article Infectious Diseases

Safety and efficacy of artemisinin-piperaquine for treatment of COVID-19: an open-label, non-randomised and controlled trial

Guoming Li et al.

Summary: There are no effective therapies for patients with coronavirus disease-2019 (COVID-19). In patients with mild-to-moderate COVID-19, the time to reach undetectable SARS-CoV-2 was significantly shorter in the artemisinin-piperaquine group than that in the control group. However, physicians should consider QT interval changes before using artemisinin-piperaquine.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Review Biochemistry & Molecular Biology

Structural insights into SARS-CoV-2 proteins

Rimanshee Arya et al.

Summary: The unprecedented scale of the ongoing COVID-19 pandemic has led to an intensive global scientific effort to understand various aspects of the disease in a short period. More than three hundred experimental structures of SARS-CoV-2 proteins have been determined recently, revealing the intricate workings of the viral machinery and their potential as drug targets.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Characterization of the Trans-Epithelial Transport of Green Tea (C. sinensis) Catechin Extracts with In Vitro Inhibitory Effect against the SARS-CoV-2 Papain-like Protease Activity

Carmela Maria Montone et al.

Summary: This study describes an untargeted analytical approach to screen, identify, and characterize green tea catechin extracts with inhibitory effects against SARS-CoV-2 PLpro. Fraction 5 showed the highest inhibitory activity, primarily absorbing the most abundant compound ECG. The synergistic effects of the crude extract components compared to isolated ECG were highlighted in this research.

MOLECULES (2021)

Article Respiratory System

Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?

Dominic L. Sykes et al.

Summary: Recent studies have shown that COVID-19 patients may experience lasting symptoms, with females being more likely to report residual symptoms. The phenomenon of Long-COVID may not be solely attributed to the impact of SARS-CoV-2, indicating a potential role of biopsychosocial effects of COVID-19 in its etiology.
Article Biochemistry & Molecular Biology

SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome

Anna Maria Sardanelli et al.

Summary: The study analyzed substances in the human metabolome capable of binding the active site of SARS-CoV-2 main protease. It revealed that silybin and silymarin, derived from milk thistle, have antiviral activities and potential as a therapeutic strategy against COVID-19.

MOLECULES (2021)

Article Multidisciplinary Sciences

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

Dafydd R. Owen et al.

Summary: PF-07321332, an orally bioavailable SARS-CoV-2 main protease inhibitor, has been discovered with in vitro pan-human coronavirus antiviral activity and excellent off-target selectivity and in vivo safety profiles. This new drug has shown promise in countering the threat of COVID-19 with its oral activity and safety in clinical trials.

SCIENCE (2021)

Article Multidisciplinary Sciences

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Jerzy Osipiuk et al.

Summary: The study focused on papain-like protease (PLpro) as a potential target for antivirals against SARS-CoV-2, identifying inhibitors and their interactions with the enzyme. The findings demonstrate the potential for developing high-affinity inhibitors through structure-based drug design efforts targeting PLpro.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

Zinuo Chen et al.

Summary: The study identified two natural products, ginkgolic acid and anacardic acid, as inhibitors of SARS-CoV-2, with dual inhibition effects on both the papain-like protease (PLpro) and the 3-chymotrypsin-like protease (3CL(pro)). These compounds were characterized as irreversible inhibitors against both 3CL(pro) and PLpro, and were found to inhibit SARS-CoV-2 replication in vitro at nontoxic concentrations, showing promise as potential antivirals against SARS-CoV-2.

CELL AND BIOSCIENCE (2021)

Article Multidisciplinary Sciences

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Britton Boras et al.

Summary: Researchers found that PF-07304814 exhibits broad-spectrum activity in inhibiting SARS-CoV and SARS-CoV-2, supported by its ADME and safety profile for clinical development. The 3CL protease, crucial in various coronaviruses, is effectively inhibited by PF-00835231 as a single agent, and shows even better results in combination with remdesivir.

NATURE COMMUNICATIONS (2021)

Review Chemistry, Multidisciplinary

Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

Hylemariam Mihiretie Mengist et al.

Summary: The COVID-19 pandemic continues to devastate the world without approved antiviral drugs or vaccines, leading to rising cases and deaths. Current patient management relies on supportive care and repurposed drugs, while ongoing studies focus on potential inhibitors to the main protease of SARS-CoV-2.

FRONTIERS IN CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots

Joao P. Baixinho et al.

Summary: A new strategy for sesquiterpene lactone extraction from chicory roots waste was developed and optimized, showing potential for converting waste into valuable products. The extraction with supercritical CO2 yielded rich fractions of sesquiterpene lactones, offering a selective alternative to conventional extraction methods.

MOLECULES (2021)

Article Chemistry, Multidisciplinary

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs

Annalisa Tito et al.

Summary: Plant extracts rich in bioactive compounds may have antiviral activities against SARS-CoV-2, presenting new opportunities for innovative therapies in the fight against the virus.

FRONTIERS IN CHEMISTRY (2021)

Article Chemistry, Physical

Inhibitory efficacy of RNA virus drugs against SARS-CoV-2 proteins: An extensive study

Manab Mandal et al.

Summary: In this study, the inhibitory efficacy of 16 RNA virus drugs against RdRp, Mpro, and PLpro proteins of SARS-CoV-2 was comprehensively analyzed. Baloxavir marboxil (BMX) showed the highest binding energy and strong interactions with these proteins, potentially inhibiting the overall transcription process of SARS-CoV-2. Molecular dynamics simulations revealed noticeable conformational alterations suggesting a significant effect on the RdRp protein.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Biochemistry & Molecular Biology

Bioactivities of Phenolic Compounds from Kiwifruit and Persimmon

Young-Mo Kim et al.

Summary: The study found that kiwifruit and persimmon have health properties in preventing heart disease, with kiwifruit showing stronger reactivity and quenching properties compared to persimmon. The interaction between polyphenols of these fruits and human serum proteins may serve as predictors for coronary artery disease (CAD).

MOLECULES (2021)

Article Food Science & Technology

Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CLPro) Activity

Carla Guijarro-Real et al.

Summary: Research has identified plant extracts and molecules as potential treatments for COVID-19, laying the groundwork for future chemical, in vivo, and clinical trials.
Article Biochemistry & Molecular Biology

Molecular docking of potential SARS-CoV-2 papain-like protease inhibitors

Daoqun Li et al.

Summary: The study identified potential inhibitors of the SARS-CoV-2 papain-like protease using an in silico molecular docking approach, with Neobavaisoflavone showing the highest binding energy. These compounds may be promising candidates for therapeutic intervention against COVID-19 by targeting crucial catalytic residues of the protease.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Processing of the SARS-CoV pp1a/ab nsp7-10 region

Boris Krichel et al.

BIOCHEMICAL JOURNAL (2020)

Article Infectious Diseases

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

Chih-Cheng Lai et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Chemistry, Medicinal

Anti-SARS-CoV-2 Potential of Artemisinins In Vitro

Ruiyuan Cao et al.

ACS INFECTIOUS DISEASES (2020)

Article Biochemistry & Molecular Biology

Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease

Yuliana K. Bosken et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Multidisciplinary Sciences

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk Shin et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography

Daniel W. Kneller et al.

NATURE COMMUNICATIONS (2020)

Review Biochemical Research Methods

Targeting Proteases for Treating COVID-19

Binquan Luan et al.

JOURNAL OF PROTEOME RESEARCH (2020)

Article Multidisciplinary Sciences

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong et al.

NATURE COMMUNICATIONS (2020)

Article Integrative & Complementary Medicine

Inhibition of influenza virus via a sesquiterpene fraction isolated from Laggera pterodonta by targeting the NF-κB and p38 pathways

YuTao Wang et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Review Pharmacology & Pharmacy

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

Yahira M. Baez-Santos et al.

ANTIVIRAL RESEARCH (2015)

Review Toxicology

Sesquiterpene lactones: Adverse health effects and toxicity mechanisms

M. Helena R. Amorim et al.

CRITICAL REVIEWS IN TOXICOLOGY (2013)

Review Biochemistry & Molecular Biology

Sesquiterpenoids Lactones: Benefits to Plants and People

Martin Chadwick et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Biochemistry & Molecular Biology

Amino-derivatives of the sesquiterpene lactone class of natural products as prodrugs

James R. Woods et al.

MEDCHEMCOMM (2013)

Article Biochemistry & Molecular Biology

Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases

Ji-Young Park et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

Article Integrative & Complementary Medicine

Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3)

CN Chen et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2005)

Article Biochemistry & Molecular Biology

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

JE Blanchard et al.

CHEMISTRY & BIOLOGY (2004)

Article Chemistry, Medicinal

Molecular properties that influence the oral bioavailability of drug candidates

DF Veber et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)