3-(Propylthio)propane-1-sulfonic acid immobilized on functionalized magnetic nanoparticles as an efficient catalyst for one-pot synthesis of dihydrotetrazolo[1,5-a]pyrimidine and tetrahydrotetrazolo[5,1-b]quinazolinone derivatives

An efficient and reusable catalyst, which is 3-(propylthio)propane-1-sulfonic acid immobillized on functionalized magnetic nanoparticles [PTPSA@SiO2-Fe3O4], has been synthesized. For the first time, it is highlighted under solvent-free conditions for the catalytic activity in multicomponent synthesis of dihydrotetrazolo[1,5-a]pyrimidines, dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates and tetrahydrotetrazolo[5,1-b]quinazolinones. The structure of the catalyst was well confirmed by characterization techniques, such as FT-IR, TGA, SEM-EDX, elemental mapping, TEM, VSM and elemental analysis. Besides, this unique catalyst was found to be effectual up to six cycles, which made it spotlighted. Recyclability of catalyst, excellent yield of the products, short reaction time and clean reaction profile are the advantages of the present protocol.

Automated summary

An efficient and reusable catalyst has been synthesized and demonstrated high catalytic activity in the synthesis of multicomponent products under solvent-free conditions. The structure of the catalyst has been confirmed through various characterization techniques, and it has shown excellent recyclability in testing. The catalyst's recyclability, high product yield, short reaction time, and clean reaction profile make it promising for potential applications.