期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 19, 期 9, 页码 971-992出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-022-00905-x
关键词
Pyroptosis; inflammasome; influencing factors; pyroptosis-associated diseases; antitumor; targeted therapy
类别
资金
- National Key Research and Development Program of China [2021YFA1101000]
- Chinese National Natural Science Funds [U20A201376, U20A20393, 31925013, 82041009, 31871405, 32125016, 92169122, 31701232, 32025011, 31822031, 31970664, 31961160725]
- Science and Technology Plan Project of Suzhou [SYS2019020]
- Jiangsu National Science Foundation [BK20180043]
- Natural Science Foundation of Zhejiang Province [LZ19C070001]
- Key Project of University Natural Science Foundation of Jiangsu Province [19KJA550003]
This article reviews the mechanisms, newly discovered influencing factors, anti-tumoral properties, and applications of pyroptosis in various diseases. Moreover, it provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and addresses the challenges and future directions in the field.
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses. Pyroptosis, an innate immune response, can be triggered by the activation of inflammasomes by various influencing factors. Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11, both of which cleave gasdermin D to release its N-terminal domain, which can bind membrane lipids and perforate the cell membrane. Here, we review the latest advancements in research on the mechanisms of pyroptosis, newly discovered influencing factors, antitumoral properties, and applications in various diseases. Moreover, this review also provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and finally challenges and future directions in the field.
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