期刊
FRONTIERS IN IMMUNOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2016.00378
关键词
Wnt; beta-catenin; NF-kappa B; gene expression; signaling pathways
类别
资金
- Kanton of Zurich
- Swiss National Science Foundation [310030_157019]
- Swiss National Science Foundation (SNF) [310030_157019] Funding Source: Swiss National Science Foundation (SNF)
Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/beta-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at least partially, due to either repressing or enhancing the NF-kappa B pathway. Similarly, the NF-kappa B pathway either positively or negatively regulates Wnt/beta-catenin signaling. Different components of the two pathways are involved in this crosstalk, forming a complex regulatory network. This review summarizes our current understanding of the molecular mechanisms underlying the cross-regulation between the two pathways and discusses their involvement in inflammation and inflammation-associated diseases such as cancer.
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