期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 1-12出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00620
关键词
mast cell; immune system; inflammatory mediators; systemic hypoxia; atherogenesis
类别
资金
- Department of Surgery (JGW)
- Department of Medicine (KND) at the University of Kansas Medical Center, National Institutes of Health [R01-HL070101, 3R01-HL0701-04S1]
- Joseph and Elizabeth Carey Arthritis Fund
- Audrey E. Smith Medical Research
- Kansas University Endowment Association
Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells are known to regulate vasodilation, vascular homeostasis, innate and adaptive immune responses, angiogenesis, and venom detoxification. On the other hand, mast cells have also been implicated in the pathophysiology of many diseases, including allergy, asthma, anaphylaxis, gastrointestinal disorders, many types of malignancies, and cardiovascular diseases. This review summarizes the current understanding of the role of mast cells in many pathophysiological conditions.
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