期刊
RSC ADVANCES
卷 12, 期 35, 页码 22377-22384出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra02639b
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资金
- National Natural Science Foundation of China [82073744, 31872617]
- CAMS Innovation Fund for Medical Sciences [2021-I2M-1-055, 2019-I2M-1-005]
- National Mega-project for Innovative Drugs [2019ZX09721001-004-006]
- National Microbial Resource Center [NMRC-2021-3]
Three new chromanone dimer derivatives, paecilins F-H (1-3), were isolated from mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated and their configurations were resolved. Compounds 5 and 11 showed significant anti-influenza A virus activities, compounds 8 and 9 exhibited cytotoxic activities against the MIA-PaCa-2 cell line, and compound 10 showed antibacterial activities against Bacillus cereus.
Three new chromanone dimer derivatives, paecilins F-H (1-3) and ten known compounds (4-13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1-3 were resolved by quantum chemical calculations of NMR shifts and ECD spectra. Compounds 5 and 11 showed significant anti-influenza A virus activities with IC50 values of 5.6 and 6.9 mu M, respectively. Compounds 8 and 9 displayed cytotoxic activities against the MIA-PaCa-2 cell line with IC50 values of 2.6 and 2.1 mu M, respectively. Compound 10 exhibited antibacterial activities against Bacillus cereus with a MIC value of 4 mu g mL(-1).
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