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Natural product total synthesis using rearrangement reactions

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ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 19, 页码 5383-5394

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01040b

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  1. National Natural Science Foundation of China [21871161, 22171161]

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Total synthesis of natural products is crucial due to their structural complexity and biological activities. The rapid construction of core skeletons, precise stereochemistry control, and suitable synthons identification are key concerns, where rearrangement reactions can simplify the overall synthesis process.
Total synthesis of natural products has been an important pursuit in chemical synthesis due to their fascinating structural complexity and/or interesting biological activities. In most synthetic designs, the rapid construction of the core skeletons, the precise control of stereochemistry, and the identification of suitable synthons are key concerns, which, to a large extent, account for the overall synthetic efficiency. This review will highlight how rearrangement reactions can contribute in addressing these three concerns, thus simplifying the total synthesis campaigns.

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