期刊
FRONTIERS IN IMMUNOLOGY
卷 7, 期 -, 页码 1-7出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2016.00020
关键词
tumor microenvironment; T lymphocyte activation; immune escape; reactive nitrogen species; immunotherapy
类别
资金
- ERC [322823]
- [602363]
- European Research Council (ERC) [322823] Funding Source: European Research Council (ERC)
Tumor microenvironment is characterized by a consistent reduction in oxygen and blood borne nutrients that significantly affects the metabolism of distinct cell subsets. Immune cells populating malignant lesions need to activate alternative pathways to overcome tumor-prolonged nutrient deprivation. In particular, the metabolic switch occurring in transforming tissues dramatically impacts on tumor-infiltrating T cell biology. Remarkably, the recruitment and activation of T cell within cancers are instrumental for effective antitumor response. Therefore, T cell metabolic adaptation acts as crucial checkpoint hijacked by tumors to dampen antitumor immunity.
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