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Regulated cell death (RCD) in cancer: key pathways and targeted therapies

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Oncology

Inhibiting Src-mediated PARP1 tyrosine phosphorylation confers synthetic lethality to PARP1 inhibition in HCC

Caiyu Sun et al.

Summary: This study identified Src and PARP1 as novel synthetic lethal partners, and the combination therapy showed significant anti-tumor effects without causing obvious side effects. The findings suggest that targeting both PARP1 and Src may broaden the strategies for HCC treatment and benefit patients with high Src activation and resistance to PARP1 inhibitors alone.

CANCER LETTERS (2022)

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Article Biochemistry & Molecular Biology

Dibenzoylmethane derivative inhibits melanoma cancer in vitro and in vivo through induction of intrinsic and extrinsic apoptotic pathways

Fernanda Rodrigues Nascimento et al.

Summary: DPBP has been found to have high in vitro antineoplastic activity against melanoma cells, inducing tumor cell death through apoptosis pathways with high selectivity. Treatment with DPBP reduced tumor volume and did not cause hepatomegaly or nephrotoxicity.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Pharmacology & Pharmacy

Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models

Minru Liao et al.

Summary: This study identified angoriside C (AC) and 3,5-dicaffeoylquinic acid (3,5-DiCQA) as the main active components of Si-MiaoYong-An decoction (SMYAD) and investigated their mechanisms in improving heart function and alleviating myocardial inflammation.

PHARMACOLOGICAL RESEARCH (2022)

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Review Pharmacology & Pharmacy

Programming inflammatory cell death for therapy

Shelbi Christgen et al.

Summary: Programmed cell death (PCD) is crucial for organism development and host defense, but dysregulation can lead to diseases. Modulating cell death has therapeutic potential, and targeting upstream sensors and signaling molecules is important. Multiple PCD pathways are regulated by these molecules and offer potential for therapeutic intervention.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Pharmacology & Pharmacy

RETRA induces necroptosis in cervical cancer cells through RIPK1, RIPK3, MLKL and increased ROS production

Suchitra Mohanty et al.

Summary: The study found that RETRA selectively induces necroptosis in cervical cancer cells without cytotoxic effects on normal cells. The induction of cell death by RETRA is associated with mitochondrial hyperpolarization and increased ROS production, emphasizing its importance in the treatment of cervical cancer.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Chemistry, Physical

A cascaded copper-based nanocatalyst by modulating glutathione and cyclooxygenase-2 for hepatocellular carcinoma therapy

Hailong Tian et al.

Summary: A novel cascaded copper-based metal-organic framework therapeutic nanocatalyst was reported for amplified hepatocellular carcinoma therapy by integrating a COX-2 inhibitor and a chemotherapeutic agent to trigger ferroptosis-mediated therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Oncology

Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies

Minru Liao et al.

Summary: This review summarizes the molecular mechanisms of seven major RCD subroutines related to TNBC and the latest progress of small-molecule compounds targeting these subroutines. The combined strategies of different drugs regulating RCD subroutines have therapeutic potential for TNBC. Several small-molecule compounds have shown promising results in clinical trials for TNBC by targeting RCD subroutines.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Review Pharmacology & Pharmacy

The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy

Alakananda Basu

Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Pharmacology & Pharmacy

A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis

Jingwen Zhang et al.

Summary: This study revealed a novel mechanism of ubiquitin-dependent p53 degradation via the MDMX-E6AP axis in cervical carcinogenesis. The small-molecule inhibitor of MDMX, XI-011, showed robust anti-proliferation activity in cervical cancer cell lines and promoted apoptosis by stabilizing p53. XI-011 also inhibited tumor growth in mice and enhanced the cytotoxic activity of cisplatin.

PHARMACOLOGICAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer

Xiang-ling Chen et al.

Summary: DCZ5248 is a novel dual inhibitor targeting both Hsp90 and autophagy, showing potent antitumor activity against colon cancer cells by inducing degradation of Hsp90 client proteins and inhibiting late-stage autophagy. The inhibition of both Hsp90 function and autophagy by DCZ5248 led to G(1)-phase cell cycle arrest, apoptosis, and significant antitumor effects in vitro and in vivo, making it a promising candidate for colon cancer therapy.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Chemistry, Multidisciplinary

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

Ji Feng et al.

Summary: ACSL4 plays a crucial role in sorafenib treatment and its high expression may predict sensitivity of HCC patients to sorafenib. The findings of this study could have important translational impacts in the precise treatment of HCC patients.

ACTA PHARMACOLOGICA SINICA (2021)

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Review Chemistry, Medicinal

Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells

Cristina Trejo-Solis et al.

Summary: The Wnt/β-catenin signaling pathway plays crucial roles in various cancer types, affecting cell survival, proliferation, angiogenesis, migration, invasion, metastasis, and stem cell renewal. However, the pathway can have dual effects, promoting both cell proliferation and apoptosis depending on the cellular context. Understanding the mechanisms behind these effects could lead to new therapeutic opportunities in cancer treatment.

PHARMACEUTICALS (2021)

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Article Gastroenterology & Hepatology

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis

Antonio Di Grazia et al.

Summary: The study suggests that increased FMRP in colon cancer may be associated with inhibiting the necroptotic pathway by regulating RIPK1 expression.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Cell Biology

Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

Wen Xu et al.

Aging-US (2021)

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Article Cell Biology

Identification of autophagic target RAB13 with small-molecule inhibitor in low-grade glioma via integrated multi-omics approaches coupled with virtual screening of traditional Chinese medicine databases

Wei Su et al.

Summary: This study identified the key autophagic regulators ZFP36L2 and Rab13 in LGG progression, and demonstrated that gallic acid is a small molecular inhibitor of RAB13, which negatively regulates autophagy and provides a possible small molecular medicine for the subsequent treatment of LGG.

CELL PROLIFERATION (2021)

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Article Gastroenterology & Hepatology

Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma

Shumei Song et al.

Summary: Gastro-oesophageal cancers (GEC) are known for their therapy resistance and poor prognosis. Research on the BCL-2 inhibitor AT101 has shown promising antitumour effects by targeting cancer stem cells (CSCs) and antiapoptotic pathways, with preclinical and clinical data supporting its potential as a novel therapy for GEC patients.

GUT (2021)

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Review Biochemistry & Molecular Biology

The Dual Role of Autophagy in Cancer Development and a Therapeutic Strategy for Cancer by Targeting Autophagy

Chul Won Yun et al.

Summary: Autophagy is a cellular degradation process that plays a role in regulating tumorigenesis, metastasis, cancer stem cells, and resistance to anticancer agents. While modulating autophagy may be a promising approach in anticancer therapy, its dual roles present limitations in its application.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

Kohsuke Tsuchiya

Summary: Pyroptosis is a regulated form of cell death, executed by Gasdermines (GSDMs) that form pores in the plasma membrane leading to cell lysis. Pyroptotic cells release pro-inflammatory molecules, eliciting inflammation and immune responses. Recent studies have advanced our understanding of pyroptosis mechanisms and roles, which may aid in the development of cancer immunotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Novel PI3K/Akt/mTOR signaling inhibitor, W922, prevents colorectal cancer growth via the regulation of autophagy

Jin Wang et al.

Summary: W922, a novel PI3K/Akt/mTOR pathway inhibitor, shows efficient anti-tumor effects on colorectal cancer cells, especially on HCT116 cells. It inhibits cell viability and proliferation in a concentration- and time-dependent manner, with proteomic alterations associated with cell cycle arrest and autophagy induction. Co-treatment with an autophagy inhibitor leads to impaired cell cycle arrest and enhanced apoptosis, suggesting a promising therapeutic strategy for colorectal cancer.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Pharmacology & Pharmacy

Inhibition of autophagy by YC-1 promotes gefitinib induced apoptosis by targeting FOXO1 in gefitinib-resistant NSCLC cells

Hui Hu et al.

Summary: Non-small cell lung cancer (NSCLC) is the most common cancer in the world, and Gefitinib has been shown to be effective in treating NSCLC. However, innate and acquired resistance present challenges in therapy. Inhibition of autophagy is considered a promising strategy to overcome resistance.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Plant Sciences

Trans-chalcone induces death by autophagy mediated by p53 up-regulation and β-catenin down-regulation on human hepatocellular carcinoma HuH7.5 cell line

Elaine da Silva Siqueira et al.

Summary: The study demonstrated that trans-chalcone exerts significant cytotoxic effects on human HCC HuH7.5 cells without toxicity to non-cancerous cells. It induces mitochondrial membrane damage, G0/G1 cell cycle arrest, decreases in beta-catenin levels, and promotes autophagic cell death, ultimately reducing the metastatic capacity of HuH7.5 cells.

PHYTOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells

Tae Woo Kim et al.

Summary: The study found that APG can treat gastric cancer by promoting autophagic cell death, increasing levels of ATG5, LC3-II, and phosphorylation of AMPK and ULK1, while down-regulating p-mTOR and p62. Additionally, APG induces autophagic cell death through the activation of the PERK signaling, indicating an endoplasmic reticulum stress response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Potential of antiviral drug oseltamivir for the treatment of liver cancer

Pei-Ju Huang et al.

Summary: This study investigated the effects of anti-hepatitis virus drugs lamivudine and ribavirin, and anti-influenza virus drug oseltamivir on liver cancer cells. The results demonstrated that oseltamivir induced both apoptosis and autophagy in liver cancer cells, suggesting a potential alternative approach for treating liver cancer.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Oncology

Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?

Zhibin Zhang et al.

Summary: The research highlights the role of gasdermin-mediated inflammatory death in promoting antitumor immunity and converting immune cell killing to inflammatory pyroptosis. This may enhance the effectiveness of immunotherapy but also increase therapy-related toxicity, requiring further study to understand its regulation and potential therapeutic applications.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Pharmacology & Pharmacy

Isorhamnetin Enhances the Radiosensitivity of A549 Cells Through Interleukin-13 and the NF-κB Signaling Pathway

Yarong Du et al.

Summary: Isorhamnetin (ISO) pretreatment enhances radiosensitivity of A549 cells by inducing apoptosis, disrupting mitochondrial membrane potential, and modulating NF-kappa B activity. The expression of anti-inflammatory cytokine IL-13 is positively correlated with ISO-mediated radiosensitization. Knockdown of IL-13 decreases ISO-induced radiosensitivity, suggesting a potential mechanism for ISO's effects on radiotherapy responsiveness.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Oncology

CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer

Ailin Chen et al.

Summary: The study identified Haspin as a synthetic lethal target, and demonstrated that the combination of Haspin inhibitor CHR-6494 and MLN8237 effectively reduces breast cancer cell viability and inhibits tumor growth.

CANCER COMMUNICATIONS (2021)

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Article Oncology

Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors

Darren C. Phillips et al.

Summary: This study highlights the activity of a hexavalent TRAIL-receptor agonistic fusion protein in preclinical models of solid tumors, distinguishing it mechanistically from other TRAIL-based therapeutics.

CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells

Yaqiong Li et al.

Summary: The study showed that dihydroartemisinin (DHA) inhibited proliferation and induced pyroptosis in breast cancer cells by activating the AIM2/caspase-3/DFNA5 axis, providing a promising therapeutic strategy for breast cancer.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Oncology

Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Pu Zhang et al.

Summary: The study identified two histone deacetylases, HDAC8 and SIRT6, whose knockout conferred synthetic lethality with the NAMPT inhibitor KPT-9274 in AML. Combination therapy with HDAC8-specific inhibitor or class I HDAC inhibitor synergistically decreased AML cell survival in a dose-dependent manner, with promising in vivo efficacy compared to monotherapy. Genetic inhibition of SIRT6 potentiated the effect of KPT-9274 on DNA repair deficiencies, suggesting a rationale for a novel combination-based treatment for AML.

CLINICAL CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The Role of mTOR Signaling as a Therapeutic Target in Cancer

Nadezhda V. Popova et al.

Summary: This review summarizes the current information on the role of phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling in cancer as a potential target for new therapy options. The mTOR and PI3K/AKT/mTORC1 (mTOR complex 1) signaling pathways are critical for regulating fundamental cell processes, and their deregulation is implicated in cancer, metabolic dysregulation, and aging. The review also discusses recent data on the structure and function of the mTOR pathway, mechanisms of deregulation in human cancers, and the use of PI3K/AKT/mTOR inhibitors in clinical studies for cancer treatment, including issues of resistance and adverse effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Medicinal

Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions

Minru Liao et al.

Summary: TNBC, the most aggressive subtype of breast cancer, lacks effective targeted therapy. Novel small-molecule drugs targeting specific molecular characteristics of TNBC may be a promising intervention, but face challenges. Emerging strategies such as dual-target drugs, drug repurposing, and combination strategies offer new insights for improving TNBC therapeutics.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

Xumin Zhou et al.

Summary: Flubendazole has potential inhibitory effects on castration-resistant prostate cancer, exerting anti-cancer effects by hindering the cell cycle and activating ferroptosis, and showing synergistic effects with 5-fluorouracil in chemotherapy.

PHARMACOLOGICAL RESEARCH (2021)

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Article Cell Biology

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

Yadong Sun et al.

Summary: Fin56 induces ferroptosis and autophagy in bladder cancer cells, with ferroptosis mechanistically depending on the autophagic machinery. Inhibition of autophagy at different stages attenuates Fin56-induced oxidative stress and GPX4 degradation. Additionally, the combination of Fin56 and Torin 2 synergistically enhances cytotoxicity against bladder cancer cells. The findings suggest that the crosstalk between ferroptosis and autophagy, along with the use of mTOR inhibitors, may offer a promising therapeutic strategy for bladder cancer.

CELL DEATH & DISEASE (2021)

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Article Oncology

Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms

Anissa Nofita Sari et al.

Summary: The study introduced a novel multimodal small molecule called Mortaparib(Plus) that abrogates mortalin-p53 interaction, reactivates p53's tumor suppression function, and induces growth arrest or apoptosis of cancer cells. The compound also leads to upregulation of p73, inactivation of PARP1 and CARF proteins, and shows potential as a new anticancer drug candidate.

CANCERS (2021)

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Review Oncology

Mutant p53 as a Regulator and Target of Autophagy

Yong Shi et al.

Summary: The article discusses the mutation of the TP53 gene in cancer and its regulatory role in autophagy, explores the potential role of mutant p53 proteins in different autophagic pathways, and discusses potential strategies for targeting mutant p53 in cancer treatment through autophagy.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Rajendra Karki et al.

Summary: The study uncovers the role of ADAR1 in suppressing ZBP1-mediated PANoptosis and promoting tumorigenesis. Additionally, the use of IFN-gamma and NEI KPT-330 regresses melanoma in a ZBP1-dependent manner, providing important insights for cancer therapeutic strategies.

CELL REPORTS (2021)

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Article Cell Biology

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Jia-yuan Zhang et al.

Summary: Pyroptosis is induced by alpha-ketoglutarate through caspase-8-mediated cleavage of GSDMC. This process involves elevation of ROS levels leading to oxidation of DR6 and endocytosis, ultimately resulting in pyroptosis. The acidic environment and production of L-2HG play a crucial role in enhancing the efficiency of alpha-KG-induced pyroptosis in cancer cells.

CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Nuclear factor-κB signaling inhibitors revert multidrug-resistance in breast cancer cells

Shifaa M. Abdin et al.

Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Oncology

Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Lin Xiao et al.

Summary: The combination of CBL0137 and panobinostat enhances nucleosome destabilization, induces an IFN response, inhibits DNA damage repair, and synergistically suppresses cancer cell growth, showing promising potential for addition to immunotherapies.

CLINICAL CANCER RESEARCH (2021)

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Article Pharmacology & Pharmacy

The Disulfiram/Copper Complex Induces Autophagic Cell Death in Colorectal Cancer by Targeting ULK1

Yeting Hu et al.

Summary: This study explores the therapeutic effect of DSF with copper on CRC, showing that the combination significantly inhibits CRC cell viability by inducing autophagy instead of apoptosis. Furthermore, a new mechanism by which DSF triggers autophagy through ULK1 is identified using whole genome CRISPR library screening.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Medicinal

An updated patent review of galectin-1 and galectin-3 inhibitors and their potential therapeutic applications (2016-present)

Aaftaab Sethi et al.

Summary: Galectins, especially galectin-1 and galectin-3, have shown high therapeutic potential in various diseases. While carbohydrate-based inhibitors have been successful, recent research on heterocyclic-based inhibitors may provide easier synthesis and better specificity in developing efficient galectin inhibitors.

EXPERT OPINION ON THERAPEUTIC PATENTS (2021)

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Article Multidisciplinary Sciences

ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

Yuanqin Yang et al.

Summary: The ZBP1-MLKL necroptotic cascade in irradiated tumor cells plays a crucial role in enhancing antitumor immunity and promoting type I interferon responses. This cascade induces cytoplasmic DNA accumulation and activates the cGAS-STING signaling pathway, leading to persistent inflammation and strengthening the antitumor effects of radiation.

SCIENCE ADVANCES (2021)

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Article Biochemistry & Molecular Biology

6-Azauridine Induces Autophagy-Mediated Cell Death via a p53-and AMPK-Dependent Pathway

Yeo-Eun Cha et al.

Summary: The study reveals that 6-AZA regulates autophagy-mediated cell death in various human cancer cells by activating lysosomal function. The compound exhibits cytotoxicity in different cancer cells with diverse mechanisms, including inducing apoptosis or causing cell cycle arrest.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways

Jang Mi Han et al.

Summary: Ampelopsin (dihydromyricetin), a plant-derived flavonoid, significantly inhibits the proliferation of two leukemia cell lines while not affecting the viability of normal cells. Its anticancer effects include cell cycle regulation, induction of apoptosis, and downregulation of signaling pathways. Ampelopsin shows promise as an attractive chemotherapeutic agent against leukemia.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Classification of Cell-in-Cell Structures: Different Phenomena with Similar Appearance

Karol Borensztejn et al.

Summary: Cell-in-cell (CIC) phenomenon, known for over 100 years, is experiencing a renaissance due to modern visualization techniques and its potential prognostic and diagnostic value for cancer patients. However, there are many unresolved questions and challenges in studying CIC, which involve complex cell interactions and molecular mechanisms.

CELLS (2021)

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Review Cell Biology

Dual Role of p73 in Cancer Microenvironment and DNA Damage Response

Julian M. Rozenberg et al.

Summary: p73 plays a dual role in cancer progression, acting as a tumor suppressor by regulating apoptosis in response to genotoxic stress and as an oncoprotein by promoting an immunosuppressive environment and immune cell differentiation in the tumor microenvironment.

CELLS (2021)

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Review Oncology

Diverse roles of FOXO family members in gastric cancer

Yu-Han Chen et al.

Summary: Gastric cancer is the fifth most diagnosed cancer and the third leading cause of cancer-related death worldwide, with patients having a poor prognosis. The FOXO subfamily of transcription factors plays important roles in cellular processes, potentially acting as both tumor suppressors and promoters, offering potential therapeutic targets and strategies for patients with gastric cancer.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Medicine, Research & Experimental

Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells

Jiasheng Chen et al.

Summary: This study demonstrates that GLA inhibits cell proliferation and induces apoptosis in melanoma cells via the NF-kappa B/p65 pathway. It also effectively suppresses tumor growth without causing toxicity to major organs.

LIFE SCIENCES (2021)

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Article Biology

The Anti-Proliferative Activity of Secondary Metabolite from the Marine Streptomyces sp. against Prostate Cancer Cells

Hung-Yu Lin et al.

Summary: Lu01-M, a secondary metabolite from marine actinomycetes, exhibited potent anti-proliferative activity against prostate cancer cells through inducing apoptosis, necroptosis, autophagy, ER stress, inhibiting colony formation and cell migration. It also induced cell cycle arrest at the G2/M phase and DNA damage, although autophagy induced survival response in cancer cells. The findings suggested that Lu01-M has the potential to be developed as an anti-cancer agent against prostate cancers.

LIFE-BASEL (2021)

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Article Cell Biology

Resveratrol Derivative, Trans-3, 5, 4′-Trimethoxystilbene Sensitizes Osteosarcoma Cells to Apoptosis via ROS-Induced Caspases Activation

Yu Feng et al.

Summary: Studies have shown that TMS sensitizes human osteosarcoma cells to TRAIL-induced apoptosis by activating ROS levels, promoting DNA damage, and activating the Bax/PUMA/p53 pathway, leading to mitochondrial and caspase-mediated apoptosis. In mouse orthotopic implantation experiments, cotreatment with TRAIL and TMS reversed resistance to apoptosis without adverse effects in normal cells.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Plant Sciences

Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer

Xiaochun Zheng et al.

Summary: The study demonstrated a synergistic effect of curcumin in combination with 5-FU on inhibiting proliferation and migration, increasing apoptosis rate, and extending survival in CRC cells. Curcumin enhanced chemosensitivity of CRC cells to 5-FU by downregulating L1 expression. This combination therapy could potentially reduce the toxicity and adverse effects of 5-FU in clinical applications.

PHYTOMEDICINE (2021)

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Article Plant Sciences

Piperine and Celecoxib synergistically inhibit colon cancer cell proliferation via modulating Wnt/β-catenin signaling pathway

Sonal Srivastava et al.

Summary: The study demonstrates that the combination of CXB and PIP offers a novel approach for the treatment of colon cancer, with significant anti-proliferative effects and modulation of apoptotic and Wnt/beta-catenin signaling pathways observed in HT-29 cells.

PHYTOMEDICINE (2021)

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Review Cell Biology

p53 and Tumor Suppression: It Takes a Network

Anthony M. Boutelle et al.

Summary: TP53 tumor suppressor gene is the most frequently mutated gene in human cancer, playing a crucial role in inhibiting tumorigenesis by transcriptionally regulating target genes. Recent studies have revealed new pathways and transcriptional targets downstream of p53 in regulating genomic integrity, metabolism, redox biology, stemness, and non-cell autonomous signaling in tumor suppression.

TRENDS IN CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Jin Young Baik et al.

Summary: The study reveals ZBP1 as a key regulator of tumor necroptosis, mediating the process during tumor development and serving as a potential drug target to control tumor metastasis. ZBP1 expression is closely related to tumor necrosis, and can trigger necroptosis under glucose deprivation.

NATURE COMMUNICATIONS (2021)

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Review Oncology

Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy

Olivia A. Diaz Arguello et al.

Summary: Cancer, a complex disease marked by evasion of apoptosis, can potentially be treated by inducing apoptosis in cancerous cells. Among the tumor necrosis factor (TNF) protein family, certain ligands possess apoptosis-inducing capabilities. Various recombinant TNF apoptosis-inducing ligands have been developed over time to improve their effectiveness in cancer treatment.

CANCERS (2021)

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Article Cell Biology

Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma

Katharina Koerholz et al.

Summary: The study found that pan-HDAC inhibitors can induce autophagy in neuroblastoma, and their combination with autophagy modulating drugs suppresses tumor growth of high-risk neuroblastoma cells.

CELLS (2021)

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Article Oncology

Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells

Yongqing Heng et al.

Summary: The neddylation pathway is overactivated in esophageal cancer, and the anticancer agent, Camptothecin (CPT), induces apoptosis and autophagy in cancer cells. CPT inhibits neddylation activity, induces ROS generation, and modulates the NF-kappa B, AMPK/mTOR/ULK1 pathways to promote protective autophagy in esophageal cancer cells. This elucidates a novel mechanism for combinational anti-ESCC therapy with CPT and inhibition of the AMPK/ULK1 pathway.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

In Vivo and In Vitro Effects of Tracheloside on Colorectal Cancer Cell Proliferation and Metastasis

Min-Kyoung Shin et al.

Summary: Recent research has shown that tracheloside (TCS) can inhibit the proliferation of colorectal cancer (CRC) cells and induce cell cycle arrest and apoptosis through its antioxidant properties. In addition, TCS was found to inhibit the metastasis of CT26 cells, suggesting it may be a novel therapeutic agent for inhibiting metastatic phenotypes of murine CRC cells.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Novel ginsenoside derivatives have shown their effects on PC-3 cells by inducing G1-phase arrest and reactive oxygen species-mediate cell apoptosis

Shengnan Xiao et al.

Summary: In this study, piperazine groups were introduced into ginsenoside to enhance its ability to induce Reactive Oxygen Species (ROS) production and apoptosis in cancer cells. A total of 27 ginsenoside piperazine derivatives were synthesized and tested for their anti-proliferative activity in cancer cell lines, with compound 6g showing the strongest inhibitory effect on PC-3 cells and inducing apoptosis through ROS production and mitochondrial pathway.

BIOORGANIC CHEMISTRY (2021)

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Article Food Science & Technology

Docosahexaenoic acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK/mTOR pathway

Chia-Han Tsai et al.

Summary: The study found that docosahexaenoic acid (DHA) promotes autophagy in breast cancer cells by upregulating oxidative stress-induced growth inhibitor 1 (OSGIN1). DHA transiently increases the generation of ROS in mitochondria and promotes autophagosome formation through activation of the p-AMPK alpha (T172)/p-Raptor (S792) signaling pathways and inactivation of the p-mTOR (S2448)/p-ULK1 (Ser757) signaling pathways, depending on the presence of OSGIN1 protein in MCF-7 cells.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Colorectal Cancer Apoptosis Induced by Dietary delta-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3

Nunzia D'Onofrio et al.

Summary: This study aimed to deepen current knowledge on the mechanism of delta VB-induced colon cancer cell death by investigating the apoptotic cascade in colorectal adenocarcinoma SW480 and SW620 cells and evaluating the molecular players of mitochondrial dysfunction. Results indicated that delta VB activated mitochondrial apoptosis through PINK1/Parkin pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms of Chemoresistance Induced by Cisplatin in NSCLC Cancer Therapy

Jolanta Kryczka et al.

Summary: Cancer cells employ various mechanisms to enhance survival, growth, and resistance to therapy. Late diagnosis contributes to low survival rates in lung cancer, often leading to advanced stages with drug resistance. Research highlights the complexity of cisplatin resistance in NSCLC, revealing key genes and pathways involved in tolerance development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Jingjing Yang et al.

Summary: This study demonstrates that metformin induces ferroptosis in an AMPK-independent manner to suppress tumor growth. Mechanistically, metformin increases the intracellular Fe2+ and lipid ROS levels by targeting the UFMylation process of SLC7A11. Additionally, combining metformin with the x(c)(-) inhibitor sulfasalazine synergistically induces ferroptosis and inhibits the proliferation of breast cancer cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Chemistry, Medicinal

Discovery of 3,5-Dimethyl-4-Sulfonyl-1H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability

Peng-Ju Zhu et al.

Summary: The study describes the rational design, synthesis, and structure-activity relationships of Mcl-1 inhibitors. The most potent compound 40 showed high affinity and superior selectivity for Mcl-1, activating the apoptosis signal pathway in an Mcl1-dependent manner.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Medicinal

Inhibiting Eukaryotic Elongation Factor 2 Kinase: An Update on Pharmacological Small-Molecule Compounds in Cancer

Shiou Zhu et al.

Summary: Eukaryotic elongation factor 2 kinase (eEF2K) is a key negative regulator of protein synthesis in tumorigenesis, with potential for cancer therapy improvement through single-target inhibitors, repurposed drugs, dual-target inhibitors, drug combination strategies, and emerging technologies.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Medicine, Research & Experimental

Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy

M. Janaki Ramaiah et al.

Summary: Genetic and epigenetic factors play crucial roles in tumor initiation and progression, with HDAC inhibitors showing promise in inducing tumor suppression by regulating chromatin conformation.

LIFE SCIENCES (2021)

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Article Oncology

Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics

Srimanta Patra et al.

Summary: Curcumin and resveratrol, bioactive phytochemicals, have shown promising chemopreventive and chemoprotective effects in cancer therapy. When combined with established anticancer drugs, they enhance anticancer activity while reducing toxicity towards normal organs through improved pharmacokinetics, pharmacodynamics, bioavailability, and metabolism.Development of drug-loaded nanoparticles, nanocarriers, liposomes, and micelles is gaining attention to improve target specificity and drug efficacy in cancer therapeutics.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Cell Biology

High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

Jana Deitersen et al.

Summary: High-throughput screening identified arzanol as a novel autophagy-modulating drug that not only induces early autophagosome biogenesis but also inhibits later autophagy events. Arzanol sensitizes bladder cancer cells to cisplatin and induces mitochondrial fragmentation, suggesting its potential as a lead compound for cancer therapy. The compound targets proteins related to mitochondria-associated quinone-binding oxidoreductases, making it a valuable tool for autophagy research.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair

Shaolu Zhang et al.

Summary: This study demonstrated synergistic anticancer effects of PARP inhibitor and PI3K inhibitor on GBM cells, affecting HR molecule expression, repair efficiency, and apoptosis induction. The combination therapy showed significantly increased anti-tumor efficacy in cell and animal models, with complemented DNA damage response and drug accumulation. This combination therapy might represent a promising therapeutic approach for GBM.

CELL DEATH & DISEASE (2021)

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Article Oncology

Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells

Yang Du et al.

Summary: Lycorine inhibits the proliferation of RCC cells by decreasing GPX4 expression, increasing ACSL4 expression, and inducing the expression of HETE and MDA to trigger ferroptosis. Additionally, ferrostatin-1 can prevent lycorine-induced ferroptosis in RCC cells.

ONCOLOGY LETTERS (2021)

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Article Biotechnology & Applied Microbiology

Curcumin Targets Both Apoptosis and Necroptosis in Acidity-Tolerant Prostate Carcinoma Cells

Yoon-Jin Lee et al.

Summary: Curcumin, derived from Curcuma longa, exhibits potent cytotoxicity against acidity-tolerant prostate cancer cells by inducing apoptosis and necroptosis through oxidative mitochondrial dysfunction and subsequent ATP depletion.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Oncology

Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor

Ahmed Elwakeel et al.

Summary: Mortaparib(Plus) is a novel multimodal small molecule that inhibits Mortalin-p53 interaction and causes reactivation of p53 function in colorectal cancer cells. In breast cancer cells with wildtype and mutant p53, it exhibited different mechanisms of action, highlighting its potential as a cancer therapeutic agent.

CANCERS (2021)

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Article Oncology

Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways

Federica Invrea et al.

Summary: This study identified a promising therapeutic strategy for clinically aggressive CRC resistant to EGFR and BRAF-targeted treatments by combining the NEDD8 pathway inhibitor pevonedistat with EGFR pathway-targeted treatments, reversing compensatory feedback loops and inhibiting tumor growth and inducing apoptosis in preclinical models.

CANCERS (2021)

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Article Oncology

NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells

Irina Jilishitz et al.

Summary: Using NP-ALT as a therapeutic approach can effectively inhibit CDK4/6 and CDK2 by targeting the tyrosine phosphorylation of p27Kip1. This treatment shows efficacy in HR+ breast cancer cells, CDK4i-resistant cells, and can induce necroptosis, particularly in cells with an ER gain of function mutation.

MOLECULAR CANCER RESEARCH (2021)

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Article Biology

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Dong-lin Yang et al.

Summary: In this study, T-96 demonstrated significant cytotoxicity to CaP cells in vitro and induced cell cycle arrest in S-phase in a dose-dependent manner. Mechanistically, T-96 promoted the initiation of autophagy but inhibited autophagic flux by inducing ROS-mediated endoplasmic reticulum (ER) stress, subsequently activating the extrinsic apoptosis pathway in CaP cells. These findings suggest that T-96-induced ER stress activates the caspase-dependent apoptosis pathway to inhibit proliferation of CaP cells.

BIOLOGICAL RESEARCH (2021)

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Article Chemistry, Physical

Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF

Rui Xu et al.

Summary: The study presents a dual-inductive nano-system for anti-cancer effects through ferroptosis and pyroptosis, utilizing a nanodrug constructed with piperlongumine-loaded metal-organic framework coated with transferrin-decorated pH sensitive lipid layer. The nanodrug demonstrated ideal anticancer effects in xenograft mice model, proving the effectiveness and promise of the dual-inductive nanoplatform for cancer treatment.

NANOSCALE HORIZONS (2021)

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Article Nutrition & Dietetics

Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells

Sang-Han Lee et al.

Summary: The combination treatment of resveratrol and DTX showed synergistic inhibitory effects on prostate carcinoma LNCaP cells by activating apoptosis and necroptosis simultaneously, with increased ROS levels, mitochondrial dysfunction, and DNA damage response. Pretreatment with the ROS scavenger N-acetylcysteine could rescue apoptosis and necroptosis.

NUTRITION RESEARCH AND PRACTICE (2021)

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Article Biochemistry & Molecular Biology

The apple dihydrochalcone phloretin suppresses growth and improves chemosensitivity of breast cancer cells via inhibition of cytoprotective autophagy

Ming Chen et al.

Summary: Phloretin effectively inhibits breast cancer cell growth, particularly under glucose-limiting conditions, by downregulating mTOR/ULK1 signaling and suppressing autophagy. It also synergistically enhances the growth inhibitory effects of chemotherapeutic agents and restores chemosensitivity in tamoxifen-resistant cell lines.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

p53-dependent elimination of aneuploid mitotic offspring by entosis

Jianqing Liang et al.

Summary: This study reveals a mechanism where entosis coupled with mitotic arrest targets aneuploid mitotic progenies for engulfment, eliminating newly born abnormal daughter cells in a p53-dependent way and implicating in the maintenance of genome integrity.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Chemistry, Medicinal

A pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF-7 breast cancer cells

Gerardo D. Anaya-Eugenio et al.

Summary: PMF isolated from Glycomis ovoidea showed antiproliferative effects against MCF-7 cells by inducing apoptosis through BCL-2 protein family regulation, cell cycle arrest, and inhibition of cell migration. Additionally, PMF did not exhibit toxicity in a zebrafish model, suggesting its potential as an alternative therapy for breast cancer.

PHYTOTHERAPY RESEARCH (2021)

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Article Biochemistry & Molecular Biology

A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation

Dagim Shiferaw Tadele et al.

Summary: Researchers have identified a novel compound DJ34 that dually targets c-Myc and p53 in a wide variety of cancers, showing particularly strong activity against LSCs.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Cell Biology

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Jingwen Jiang et al.

AUTOPHAGY (2020)

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Article Immunology

ZBP1 mediates interferon-induced necroptosis

Daowei Yang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Oncology

Bromodomain and extraterminal domain inhibition synergizes with WEE1-inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer

Yuta Takashima et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Review Biochemistry & Molecular Biology

Recruitment and Activation of the ULK1/Atg1 Kinase Complex in Selective Autophagy

Eleonora Turco et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Article Plant Sciences

20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway

Ting Xia et al.

JOURNAL OF GINSENG RESEARCH (2020)

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Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Pharmacology & Pharmacy

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

Sona Vodenkova et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Pharmacology & Pharmacy

Targeting autophagy-related protein kinases for potential therapeutic purpose

Honggang Xiang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Biochemistry & Molecular Biology

Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress

Dongfang Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

Cinobufagin induces cell cycle arrest at the S phase and promotes apoptosis in nasopharyngeal carcinoma cells

Zhaohai Pan et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Synthesis of a novel series of (Z)-3,5-disubstituted thiazolidine-2,4-diones as promising anti-breast cancer agents

Hussein El-Kashef et al.

BIOORGANIC CHEMISTRY (2020)

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Article Oncology

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

Ye Yang et al.

BMC CANCER (2020)

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Article Oncology

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Kari J. Kurppa et al.

CANCER CELL (2020)

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Review Oncology

Tumor sidedness and efficacy of first-line therapy in patients with RAS/BRAF wild-type metastatic colorectal cancer: A network meta-analysis

Chih-Chien Wu et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Immunology

Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells

Asuman Deveci Ozkan et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2020)

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Article Oncology

Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53

Satish K. Ramraj et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Biochemistry & Molecular Biology

Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway

Jinxia Qiu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells

Hyo-Jin Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/beta-catenin Signaling

Chi-Hung R. Or et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Agriculture, Multidisciplinary

Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells

Rongjun Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Cell Biology

Arctigenin induces necroptosis through mitochondrial dysfunction with CCN1 upregulation in prostate cancer cells under lactic acidosis

Yoon-Jin Lee et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

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Article Oncology

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

Dan A. Erkes et al.

CANCER DISCOVERY (2020)

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Review Oncology

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

Li Liu et al.

CANCERS (2020)

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Article Cell Biology

Tannic Acid Promotes TRAIL-Induced Extrinsic Apoptosis by Regulating Mitochondrial ROS in Human Embryonic Carcinoma Cells

Nipin Sp et al.

CELLS (2020)

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Review Cell Biology

Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases

Simonetta Pazzaglia et al.

CELLS (2020)

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Article Immunology

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Yuying Liu et al.

SCIENCE IMMUNOLOGY (2020)

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Article Cell Biology

A novel 3′,5′-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer

Yongqiang Zhang et al.

AGING-US (2020)

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Review Chemistry, Medicinal

p62 as a therapeutic target for tumor

Mengmin Tao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

Karol Bukowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Understanding MAPK Signaling Pathways in Apoptosis

Jicheng Yue et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

The p38 MAPK Signaling Activation in Colorectal Cancer upon Therapeutic Treatments

Angelina Pranteda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View

Manuela Labbozzetta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF-κB signalling participate in anti-glioblastoma of imipramine

Fei-Ting Hsu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Multidisciplinary Sciences

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou et al.

SCIENCE (2020)

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Article Chemistry, Medicinal

p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

Ying Chen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Apigetrin induces extrinsic apoptosis, autophagy and G2/M phase cell cycle arrest through PI3K/AKT/mTOR pathway in AGS human gastric cancer cell

Seong Min Kim et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

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Review Cell Biology

Life, death, and autophagy in cancer: NF-κB turns up everywhere

Daniela Verzella et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells

Yingying Wang et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

Transferrin Receptor Is a Specific Ferroptosis Marker

Huizhong Feng et al.

CELL REPORTS (2020)

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Review Chemistry, Medicinal

The role of FOXOs and autophagy in cancer and metastasis-Implications in therapeutic development

Mohd Farhan et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

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Article Multidisciplinary Sciences

A bioorthogonal system reveals antitumour immune function of pyroptosis

Qinyang Wang et al.

NATURE (2020)

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Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Myeloid cell leukemin-1 inhibitors: a growing arsenal for cancer therapy

Peng-Ju Zhu et al.

DRUG DISCOVERY TODAY (2020)

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Article Medicine, Research & Experimental

The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer

Ching-Feng Chiu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance

Jing Ma et al.

BIOORGANIC CHEMISTRY (2020)

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Article Chemistry, Medicinal

Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives

Jia-Nian Chen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Oncology

Intracellular levels of reactive oxygen species correlate with ABT-263 sensitivity in non-small-cell lung cancer cells

Keiko Ohgino et al.

CANCER SCIENCE (2020)

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Article Oncology

Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway

Jun Wang et al.

CANCER MEDICINE (2020)

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Review Oncology

Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges

De-Hua Yu et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Engineering, Biomedical

Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma

Yunfeng Gao et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Oncology

Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer

Ya Cao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Medicine, Research & Experimental

Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

Xiaoqing Hu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Synthesis of some novel methyl β-orsellinate based 3, 5-disubstituted isoxazoles and their anti-proliferative activity: Identification of potent leads active against MCF-7 breast cancer cell

Srilakshmi Tirupathamma Reddy et al.

BIOORGANIC CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Attacking the mitochondria of colorectal carcinoma by novel 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety as a new trend for chemotherapy

Magda F. Mohamed et al.

BIOORGANIC CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis

Chengui Lu et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Oncology

Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of beta-catenin/Wnt-signaling pathways in colorectal cancer

Priyanka Sharma et al.

CARCINOGENESIS (2020)

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Article Cell Biology

A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes

Tapas Patra et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death

Atsuo Takeda et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2020)

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Review Oncology

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Jimin Yuan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Oncology

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Win Topatana et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Medicine, Research & Experimental

Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway

Ali Nasrollahzadeh et al.

LIFE SCIENCES (2020)

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Article Cell Biology

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Junwei Hou et al.

NATURE CELL BIOLOGY (2020)

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Article Oncology

A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

Qiuyun Luo et al.

ONCOLOGY RESEARCH (2020)

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Article Cell Biology

Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways

Xiuhua Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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HG30, a tetrahydroanthraquinone compound isolated from the roots of Prismatomeris connate, induces apoptosis in human non-small cell lung cancer cells

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An iridium (III) complex as potent anticancer agent induces apoptosis and autophagy in B16 cells through inhibition of the AKT/mTOR pathway

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Two new Cu(II) dipeptide complexes based on 5-methyl-2-(2′-pyridyl) benzimidazole as potential antimicrobial and anticancer drugs: Special exploration of their possible anticancer mechanism

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Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Targeting EGFR-mediated autophagy as a potential strategy for cancer therapy

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INTERNATIONAL JOURNAL OF CANCER (2018)

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Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells

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Design, synthesis, and characterization of , -unsaturated carboxylic acid, and its urea based derivatives that explores novel epigenetic modulators in human non-small cell lung cancer A549 cell line

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New therapeutic strategies to treat human cancers expressing mutant p53 proteins

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Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

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Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy

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Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer

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Tetrandrine (TET) Induces Death Receptors Apo Trail R1 (DR4) and Apo Trail R2 (DR5) and Sensitizes Prostate Cancer Cells to TRAIL-Induced Apoptosis

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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

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Puerarin Inhibits Proliferation and Induces Apoptosis by Upregulation of miR-16 in Bladder Cancer Cell Line T24

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Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells

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F1012-2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy

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PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression

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Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

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BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells

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Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

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The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG

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A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma

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GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21

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Ferroptosis: A Novel Anti-tumor Action for Cisplatin

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Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

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Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

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FOXO3 Inhibits Human Gastric Adenocarcinoma (AGS) Cell Growth by Promoting Autophagy in an Acidic Microenvironment

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Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma

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Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

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Analysis of the Effect of Gentian Violet on Apoptosis and Proliferation in Cutaneous T-Cell Lymphoma in an In Vitro Study

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Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

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Aurantoside C Targets and Induces Apoptosis in Triple Negative Breast Cancer Cells

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TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

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LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation

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Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression

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Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer

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Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer

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Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

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8-C-(E-phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

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N-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy

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Mutant p53 as a target for cancer treatment

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A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells

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Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth

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Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades

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Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation

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Pancreatic Cancer-Induced Neutrophil Extracellular Traps: A Potential Contributor to Cancer-Associated Thrombosis

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Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

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Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

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NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

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Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

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Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer

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DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

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Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA

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Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes

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Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells

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Cancer cells induce interleukin-22 production from memory CD4(+) T cells via interleukin-1 to promote tumor growth

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Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo

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Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

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Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation

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Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cells

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Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IκB and Downregulation of Survivin

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Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

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Synthetic Lethality Exploitation by an Anti-Trop-2-SN-38 Antibody-Drug Conjugate, IMMU-132, Plus PARP Inhibitors in BRCA1/2-wild-type Triple-Negative Breast Cancer

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Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment

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Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells

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Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP-TEAD complex

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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

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The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

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Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy

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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

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Identification of ACSL4 as a biomarker and contributor of ferroptosis

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

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Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells

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The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway

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Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

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Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS

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CANCER LETTERS (2016)

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Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population

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Review Biochemistry & Molecular Biology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

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CELL (2016)

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Cancer therapy in the necroptosis era

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CELL DEATH AND DIFFERENTIATION (2016)

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Constitutive NF-κB activation in AML: Causes and treatment strategies

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

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First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors

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JOURNAL OF CLINICAL ONCOLOGY (2016)

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Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex

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JOURNAL OF MOLECULAR BIOLOGY (2016)

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Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers

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The International Epidemiology of Lung Cancer: Latest Trends, Disparities, and Tumor Characteristics

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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Programmed necrosis in inflammation: Toward identification of the effector molecules

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ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

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An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib

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ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

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Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas

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Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

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Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction

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CELL (2015)

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Targeting TRAIL in the treatment of cancer: new developments

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EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

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NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

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Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

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Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

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Oncogenic KRAS signalling in pancreatic cancer

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Polyphenon E, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis

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The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide

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β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

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RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

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Defective Stromal Remodeling and Neutrophil Extracellular Traps in Lymphoid Tissues Favor the Transition from Autoimmunity to Lymphoma

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MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

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CANCER LETTERS (2013)

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Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

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The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

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Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1

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Induction of mitochondrial dysfunction by poly(ADP-ribose) polymer: Implication for neuronal cell death

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mTOR is a key modulator of ageing and age-related disease

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Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

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Rab6a/a′ Are Important Golgi Regulators of Pro-Inflammatory TNF Secretion in Macrophages

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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PARP-1 protein expression in glioblastoma multiforme

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EUROPEAN JOURNAL OF HISTOCHEMISTRY (2012)

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Targeting the Fas/FasL signaling pathway in cancer therapy

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EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

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Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1

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Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

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Letter Cell Biology

Multiple death pathways in TNF-treated fibroblasts: RIP3-and RIP1-dependent and independent routes

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Transcriptional Profiling of Peripheral Blood Mononuclear Cells in Pancreatic Cancer Patients Identifies Novel Genes with Potential Diagnostic Utility

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Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

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The Inflammasome Component Nlrp3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-Associated Myeloid-Derived Suppressor Cells

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Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

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The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

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Sterile inflammation: sensing and reacting to damage

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Blocking β-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells

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Bcl-2 Modulation to Activate Apoptosis in Prostate Cancer

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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.

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TNF-α induces two distinct caspase-8 activation pathways

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Advances in neuronal cell death 2007

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A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion

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Differential sensitivity of naive and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis

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Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients

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Shikonin circumvents cancer drug resistance by induction of a necroptotic death

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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Neutrophil extracellular traps kill bacteria

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