The total synthesis of rhynchosporosides via orthogonal one-pot glycosylation and stereoselective α-glycosylation strategies

The efficient and collective synthesis of rhynchosporosides causing scald diseases has been achieved, which features orthogonal one-pot glycosylation on the basis of PTFAI glycosylation, Yu glycosylation, and PVB glycosylation and merging reagent modulation and remote anchimeric assistance (RMRAA) alpha-glucosylation strategies. The issues inherent to the thioglycoside-based orthogonal one-pot glycosylation strategy, such as aglycone transfer, have been precluded by this orthogonal one-pot glycosylation strategy, which can streamline glycan chemical synthesis.

Automated summary

Efficient and collective synthesis of rhynchosporosides, which cause scald diseases, has been achieved through an orthogonal one-pot glycosylation strategy based on PTFAI glycosylation, Yu glycosylation, and PVB glycosylation. This strategy incorporates reagent modulation and remote anchimeric assistance (RMRAA) alpha-glucosylation strategies, overcoming issues encountered in thioglycoside-based orthogonal one-pot glycosylation and streamlining glycan chemical synthesis.