AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high O-1(2) generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.

Automated summary

The integration of AIE-active Ir(III) complex and UCNPs has resulted in a promising NIR-irradiated photosensitizer UCNPs@Ir-2-N, which shows excellent performance in killing mouse cancer cells and has potential for future applications in photodynamic therapy.