4.4 Review

Nanoplatform-Based Reactive Oxygen Species Scavengers for Therapy of Ischemia-Reperfusion Injury

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer

Na Tao et al.

Summary: The study presents a multifunctional platform based on Au nanoparticles and carbon dots modified hollow black TiO2 nanosphere for reversing immunosuppression and alleviating hypoxia in the tumor microenvironment. This platform effectively kills tumor cells by eliciting immune infiltration, alleviating hypoxia, and improving sonodynamic therapy efficiency.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

Guanning Huang et al.

Summary: This study designed a translational antioxidative agent, HSA-Mn3O4, which effectively inhibits nervous system damage caused by ischemic stroke reperfusion, demonstrating neuroprotective capacity mainly by inhibiting apoptosis and endoplasmic reticulum stress to prevent brain tissue damage.

ACS NANO (2022)

Review Chemistry, Multidisciplinary

ROS-Catalytic Transition-Metal-Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Ling Li et al.

Summary: Recent research has shown that transition-metal-based enzymatic nanoagents can produce reactive oxygen species efficiently, making them promising in combating drug-resistant tumors and bacteria. Different mechanisms for ROS production and key factors for enhancing ROS levels have been carefully studied, along with discussions on the applications of these TM-EnzNAs in antitumor and antibacterial therapies.

ADVANCED FUNCTIONAL MATERIALS (2022)

Review Chemistry, Multidisciplinary

Recent Advances in Nanozymes: From Matters to Bioapplications

Yongjian Ai et al.

Summary: The article summarizes the latest developments in nanozyme research, including the preparation of different raw materials, the various enzyme-like catalytic activities of nanozymes, and their wide-ranging biological applications. Additionally, it outlines the current challenges faced by nanozymes and offers future research directions.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Multidisciplinary

A ROS-Sensitive Nanozyme-Augmented Photoacoustic Nanoprobe for Early Diagnosis and Therapy of Acute Liver Failure

Haibin Wu et al.

Summary: This study presents a ROS-sensitive nanozyme-augmented photoacoustic nanoprobe for successful in vivo imaging of ALF. The nanoprobe's deep-penetrating photoacoustic signals can be activated by the overexpressed ROS in ALF, allowing for earlier diagnosis and timely nanocatalytic therapy of ALF.

ADVANCED MATERIALS (2022)

Article Chemistry, Analytical

Kinetically Orthogonal Probe for Simultaneous Measurement of H2S and Nitroreductase: A Refined Method to Predict the Invasiveness of Tumor Cells

Jialiang Xiong et al.

Summary: Researchers developed a strategy to construct a kinetically orthogonal probe labeled KOP, which can measure the concentrations of nitroreductase and H2S and accurately indicate the invasiveness of tumors in a cellular model with complex H2S generation pathway.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Self-Cascade Uricase/Catalase Mimics Alleviate Acute Gout

Anqi Lin et al.

Summary: Uricase-based therapies for gout are limited by the accumulation of H2O2 in an arthrosis environment, but a novel Pt/CeO2 nanozyme has shown high efficiency in degrading UA and eliminating H2O2 simultaneously. This nanozyme not only improves UA degradation, but also has excellent ROS and RNS scavenging activities, leading to significant pain relief and inflammation reduction in acute gout rats.

NANO LETTERS (2022)

Article Chemistry, Multidisciplinary

Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS-NFκB pathway

Yijun Yu et al.

Summary: This study introduces a therapeutic approach for managing periodontitis using cerium oxide nanoparticles. The synthesized nanoparticles can scavenge reactive oxygen species, suppress inflammation reactions, and improve tissue restoration. The findings highlight the potential of cerium oxide nanoparticles for treating periodontitis and provide valuable insights into the application of nanozymes in inflammatory diseases.

NANOSCALE (2022)

Article Chemistry, Multidisciplinary

Tunable Assembly of Organic-Inorganic Molecules into Hierarchical Superstructures as Ligase Mimics for Enhancing Tumor Photothermal Therapy

Yongjian Ai et al.

Summary: In this study, a metal-ligand cross-linking strategy was developed for the fabrication of ferric ion-dopamine coordination hierarchical superstructures. Various superstructures with complex morphologies were synthesized, and the formation mechanism was explored. The hierarchical superstructure was used as peroxidase-like ligase mimics to enhance tumor photothermal treatment, and it showed effective tumor cell ablation in vitro and in vivo. This work opens new horizons in hierarchical superstructures and has great potential in nanozymology, biomedical science, and catalysis.
Article Chemistry, Multidisciplinary

Atomically Dispersed Cu Nanozyme with Intensive Ascorbate Peroxidase Mimic Activity Capable of Alleviating ROS-Mediated Oxidation Damage

Yuan Chen et al.

Summary: This study presents a single-atom nanozyme Cu SAs/CN with APX-like behavior, showing comparable activity and kinetics to natural APXs. Through density functional theory, the Cu-N-4 moieties in the active center of Cu SAs/CN are determined to facilitate the activation and cleavage of H2O2 molecules, resulting in fast kinetics.

ADVANCED SCIENCE (2022)

Article Chemistry, Multidisciplinary

Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury

Renyikun Yuan et al.

Summary: This study developed a strategy using Fe-Cur NPs as nanozymes to scavenge intracellular ROS and alleviate inflammation synergistically, thereby treat acute lung injury (ALI). The Fe-Cur NPs reduced levels of various inflammatory cytokines, inflammasomes, and signaling pathways, and demonstrated promising therapeutic efficiency in animal experiments. Fe-Cur NPs also effectively reduced macrophage cells and T cells, helping suppress the inflammation cytokine storm caused by ALI.

ACS CENTRAL SCIENCE (2022)

Article Chemistry, Physical

Engineering CXCL12 Biomimetic Decoy-Integrated Versatile Immunosuppressive Nanoparticle for Ischemic Stroke Therapy with Management of Overactivated Brain Immune Microenvironment

Jinjin Shi et al.

Summary: The versatile immunosuppressive nanoparticle, VIN, designed to manage the overactivated brain immune microenvironment post-ischemic stroke, demonstrates promising therapeutic effects by adsorbing and neutralizing inflammatory factors, inhibiting infiltration of inflammatory cells, promoting microglia polarization, and enhancing ROS scavenging, ultimately improving survival rates and neurological functional recovery in stroke patients.

SMALL METHODS (2022)

Article Engineering, Biomedical

Rescuing ischemic stroke by biomimetic nanovesicles through accelerated thrombolysis and sequential ischemia-reperfusion protection

Wenyan Yu et al.

Summary: In this study, a biomimetic nanovesicle was developed to accelerate thrombolysis and sequentially avoid thrombolysis-mediated reperfusion injury. The nanovesicle exhibited thrombus targeting property, photothermal conversion performance, and free radical scavenging property, enabling cascade ischemic stroke treatment.

ACTA BIOMATERIALIA (2022)

Review Medicine, Research & Experimental

Nanomedicine for Acute Brain Injuries: Insight from Decades of Cancer Nanomedicine

Rebecca M. Kandell et al.

Summary: Acute brain injuries, such as traumatic brain injury and stroke, affect 85 million people worldwide annually. Current FDA-approved therapies are limited in treating brain diseases after acute brain injury. Leveraging nanomaterials based on cancer nanomedicine research could offer innovative solutions for designing novel nanomedicines for acute brain injuries.

MOLECULAR PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Targeted Treatment of Ischemic Stroke by Bioactive Nanoparticle-Derived Reactive Oxygen Species Responsive and Inflammation-Resolving Nanotherapies

Jichao Yuan et al.

Summary: This study reports bioactive nanoparticle-derived multifunctional nanotherapies for ischemic stroke, showing significant therapeutic effects through antioxidative, anti-inflammatory, and antiapoptotic mechanisms. The nanomedicines derived from TPCD NPs have potential as promising targeted therapies for stroke and other inflammation-associated cerebrovascular diseases.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers

Yue Zhang et al.

Summary: Integrating protein reconstruction technology and nanotechnology, an artificial hybrid nanozyme with superoxide dismutase and catalase-like activities was developed to target mitochondria and demonstrate protective effects in mitochondrial oxidative injury and heart function recovery. This innovative approach highlights the potential of enzyme mimics in regenerative medicine for alleviating oxidative damage.

ADVANCED MATERIALS (2021)

Article Chemistry, Physical

Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation

Yongjian Ai et al.

Summary: The study introduces a highly efficient nanozyme, Se@Me@MnO2, that demonstrates potential for intracellular antioxidation and anti-inflammation by scavenging ROS through multiple enzyme activities. The nanozyme shows promise for treating inflammatory diseases due to its ability to quickly clear hydrogen peroxide, hydroxyl radical, and superoxide anion through synergistic and fast electron transfer effects.

NANO RESEARCH (2021)

Article Nanoscience & Nanotechnology

Kupffer cell-targeting strategy for the protection of hepatic ischemia/reperfusion injury

Qingqing Dai et al.

Summary: This study shows that rare earth upconversion nanoparticles (UCNs) can specifically deplete Kupffer cells through pyroptosis, reducing the release of inflammatory cytokines and improving hepatic ischemia reperfusion injury. The administration of the caspase-1 inhibitor can rescue the UCN-induced pyroptosis of Kupffer cells.

NANOTECHNOLOGY (2021)

Article Polymer Science

Virus-Mimicking Liposomal System Based on Dendritic Lipopeptides for Efficient Prevention Ischemia/Reperfusion Injury in the Mouse Liver

Rong Zhuang et al.

Summary: A virus-mimicking liposomal system based on dendritic lipopeptides is reported for efficient prevention of hepatic ischemia-reperfusion injury (IRI). These liposomes have virus-like nanostructures and components, with viral-like infections to liver tissue, cells, and organelles. The viral mimics show distinguished features such as viral envelope-like structure to avoid the host immune system, well-defined nanostructure, and viral capsids mimic for enhanced liver cell uptake and mitochondrial targeting.

ACS MACRO LETTERS (2021)

Review Nanoscience & Nanotechnology

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Yuanyuan Jin et al.

Summary: Nanobiomaterials show great promise in the treatment of ALF, enhancing drug bioavailability and increasing therapeutic agent accumulation in the liver for more effective treatment. Additionally, stimuli-responsive, optical, or magnetic nanomaterials offer potential in therapeutical, diagnostic, and imaging applications in ALF.

NANO-MICRO LETTERS (2021)

Review Chemistry, Multidisciplinary

Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment

Chenyang Zhang et al.

Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

Zhenhua Li et al.

Summary: In this study, a ROS-sensitive cross-linked poly(vinyl alcohol) (PVA) hydrogel was synthesized to deliver basic fibroblast growth factor (bFGF) for myocardial repair, showing significant therapeutic effects in protecting cardiac function, reducing fibrosis, and enhancing angiomyogenesis. Additionally, the safety and feasibility of minimally invasive injection and access into the pericardial cavity in both pigs and human patients were demonstrated.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Multidisciplinary Sciences

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Qinjie Weng et al.

Summary: Catalytic activity tunable ceria nanoparticles have been reported as potential agents for preventing chemotherapy-induced acute kidney injury without compromising the efficacy of chemotherapeutic agents. This context-dependent reactive oxygen species scavenger shows promise for clinical application in cancer patients.

NATURE COMMUNICATIONS (2021)

Review Chemistry, Multidisciplinary

Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools

Leila Pourtalebi Jahromi et al.

Summary: In recent decades, diverse immune cells have been explored for their potential as therapeutic and diagnostic cell-based microrobots for challenging disorders. These systems leverage the unique characteristics and functions of immune cells to address a variety of diseases.

ADVANCED SCIENCE (2021)

Article Instruments & Instrumentation

Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury

Margarida Ferreira-Silva et al.

Summary: Hepatic ischemia and reperfusion injury (IRI) is an acute inflammatory process for which there is currently no effective treatment in the clinic. Drug delivery nanosystems have shown promise in providing a new approach to therapy, with the ability to target specific compounds and enhance treatment efficacy through passive or active targeting.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Article Nanoscience & Nanotechnology

Nanozyme Impregnated Mesenchymal Stem Cells for Hepatic Ischemia-Reperfusion Injury Alleviation

Abhishek Sahu et al.

Summary: Mesenchymal stem cell (MSC) based therapy shows great potential in treating diseases, but the low viability of transplanted cells in injured tissues due to high oxidative stress levels is a major obstacle. Using a ROS-scavenging nanozyme to protect MSCs from oxidative stress-mediated apoptosis can significantly improve therapeutic potential and survival in high oxidative stress conditions. Incorporating nanozymes into MSCs is a simple and efficient way to enhance MSC-based cell therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Sequential Therapy of Acute Kidney Injury with a DNA Nanodevice

Qian Chen et al.

Summary: The development of a renal-accumulating DNA nanodevice in this study offers promising protection for acute kidney injury patients in different stages, with potential for providing durable and pathogenic treatment for kidney dysfunction based on the pathophysiological events caused by ischemia-reperfusion.

NANO LETTERS (2021)

Review Chemistry, Multidisciplinary

Nanotheranostics for the Management of Hepatic Ischemia-Reperfusion Injury

Yu Guan et al.

Summary: Nanomaterials offer targeted delivery and controllable release of contrast agents and therapeutic drugs in hepatic IRI regions, improving imaging sensitivity and therapeutic effects, making them a novel alternative for hepatic IRI diagnosis and therapy.
Article Multidisciplinary Sciences

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Wei Feng et al.

Summary: Materials with enzymatic-like activities, such as 2D vanadium carbide MXene nanozymes, show promise in treating inflammatory and neurodegenerative diseases mediated by reactive oxygen species.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Dual Enzyme Mimics Based on Metal-Ligand Cross-Linking Strategy for Accelerating Ascorbate Oxidation and Enhancing Tumor Therapy

Yongjian Ai et al.

Summary: The development of high-efficiency nanozymes with excellent oxidase-like and peroxidase-like enzyme activities is significant for enhancing the oxidation of ascorbate to improve cancer cell ablation efficacy. The fabricated nanozyme can rapidly and completely oxidize ascorbate within 20 minutes, leading to tumor cell death through the generation of superoxide free radicals and hydrogen peroxide.Overall, the research shows a promising enhancement in anti-tumor efficacy through ascorbate oxidation catalyzed by the developed nanozyme.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Materials Science, Multidisciplinary

Stretchable and Anisotropic Conductive Composite Hydrogel as Therapeutic Cardiac Patches

Chenlong Wang et al.

Summary: By utilizing a stretch-induced strategy, a new hybrid hydrogel with excellent stretchability and outstanding anisotropic conductivity has been fabricated. This hybrid hydrogel has been successfully applied as a therapeutic cardiac patch, promoting elongated cell morphology and stable directional transmission of electric signals.

ACS MATERIALS LETTERS (2021)

Article Pharmacology & Pharmacy

Synergistic Photothermal and Chemical Therapy by Smart Dual-Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease

Tianzhong Li et al.

Summary: The study successfully addressed the issue of limited BBB permeability in PD treatment by utilizing a GDY nanoplatform to deliver MN. GDY exhibited excellent loading capacity, release efficiency, and therapeutic effects for correcting behavioral defects in PD mice through photothermal and chemical synergistic treatment.

ADVANCED THERAPEUTICS (2021)

Article Pharmacology & Pharmacy

Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect against Chronic Adverse Ventricular Remodeling

Peter J. Altshuler et al.

Summary: Early revascularization is crucial in reducing post-myocardial infarction morbidity, although it can lead to additional oxidative injury. This study demonstrates the use of a novel nanoparticle carrier to enhance the retention of exogenous SOD in preserving cardiac function after ischemia-reperfusion injury. The nanoparticle-encapsulated SOD exhibits similar enzyme activity as free SOD, reduces ROS damage in vitro, and improves left ventricular function in vivo, suggesting its potential as a therapy for mitigating myocardial I/R injury.

ADVANCED THERAPEUTICS (2021)

Review Pharmacology & Pharmacy

Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment

Barbara Carreira et al.

Summary: Melanoma, the most destructive and deadly skin cancer, has limited therapeutic options. Immunotherapy has emerged as a possible treatment choice for late-stage melanoma patients, but only a small percentage of patients respond to it. Current research focuses on exploring melanoma tumor biology and immunology to guide the development of combinational immunotherapies.

ADVANCED THERAPEUTICS (2021)

Review Chemistry, Multidisciplinary

Advanced Functional Materials and Cell-Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects

Christos Tapeinos et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity

Liguo Jin et al.

ADVANCED MATERIALS (2020)

Review Chemistry, Multidisciplinary

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Yongjian Ai et al.

Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

Review Neurosciences

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

Liquan Wu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Article Chemistry, Multidisciplinary

Selenium-Doped Carbon Quantum Dots Act as Broad-Spectrum Antioxidants for Acute Kidney Injury Management

Zachary T. Rosenkrans et al.

ADVANCED SCIENCE (2020)

Review Medicine, Research & Experimental

Bilirubin Nanomedicines for the Treatment of Reactive Oxygen Species (ROS)-Mediated Diseases

Zhejie Chen et al.

MOLECULAR PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

Dancing with reactive oxygen species generation and elimination in nanotheranostics for disease treatment

Zijian Zhou et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Surgery

Extracellular vesicles for treatment of solid organ ischemia-reperfusion injury

Mojahid Ali et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

Article Chemistry, Multidisciplinary

Prevention of Hepatic Ischemia-Reperfusion Injury by Carbohydrate-Derived Nanoantioxidants

Yin Long et al.

NANO LETTERS (2020)

Review Chemistry, Multidisciplinary

Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury

Weiyu Chen et al.

FRONTIERS IN CHEMISTRY (2020)

Article Materials Science, Biomaterials

Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis

Ruyi He et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Nanoscience & Nanotechnology

Nitrite-Responsive Hydrogel: Smart Drug Release Depending on the Severity of the Nitric Oxide-Related Disease

Jialiang Xiong et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Review Chemistry, Multidisciplinary

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Sandhya Clement et al.

ADVANCED SCIENCE (2020)

Review Chemistry, Physical

Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

Joon Ho Park et al.

NANOSCALE HORIZONS (2020)

Article Pharmacology & Pharmacy

Nanomedicine Revisited: Next Generation Therapies for Brain Cancer

Adip G. Bhargav et al.

ADVANCED THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Gastroenterology & Hepatology

Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

Wasim A. Dar et al.

LIVER INTERNATIONAL (2019)

Review Chemistry, Multidisciplinary

Reactive Oxygen Species (ROS)-Based Nanomedicine

Bowen Yang et al.

CHEMICAL REVIEWS (2019)

Review Chemistry, Analytical

Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test

Yongjian Ai et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection

Dalong Ni et al.

ADVANCED MATERIALS (2019)

Review Chemistry, Multidisciplinary

Antioxidative nanomaterials and biomedical applications

Yanlan Liu et al.

NANO TODAY (2019)

Article Nanoscience & Nanotechnology

Smart cancer nanomedicine

Roy van der Meel et al.

NATURE NANOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

Teng Su et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Review Cardiac & Cardiovascular Systems

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury JACC Review Topic of the Week

Sean M. Davidson et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Pharmacology & Pharmacy

A Self-Assembled Fluorescent Nanoprobe for Imaging and Therapy of Cardiac Ischemia/Reperfusion Injury

Melanie Ziegler et al.

ADVANCED THERAPEUTICS (2019)

Review Neurosciences

Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury

Anthony R. Anzell et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury

Xiao-Jing Zhang et al.

NATURE MEDICINE (2018)

Article Engineering, Biomedical

Nanoparticle-Based Therapeutics for Brain Injury

Vimala N. Bharadwaj et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Chemistry, Multidisciplinary

A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy

Xiaoyuan Ji et al.

ADVANCED MATERIALS (2018)

Article Biochemistry & Molecular Biology

The protective effect of orally administered redox nanoparticle on intestinal ischemia-reperfusion injury in mice

Tomohiro Ueda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Cell Biology

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

Meng-yu Wu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Review Biochemistry & Molecular Biology

ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection

Susana Cadenas

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Letter Cardiac & Cardiovascular Systems

LncRNA MALAT1 sponges miR-203 to promote inflammation in myocardial ischemia-reperfusion injury

Shuang Wang et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

Review Endocrinology & Metabolism

Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy

Hao Zhou et al.

JOURNAL OF PINEAL RESEARCH (2018)

News Item Biochemistry & Molecular Biology

Lipid metabolic reprogramming in hepatic ischemia-reperfusion injury

Satdarshan P. Monga

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni et al.

NATURE COMMUNICATIONS (2018)

Article Pharmacology & Pharmacy

Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer

Ye Tian et al.

ADVANCED THERAPEUTICS (2018)

Article Chemistry, Multidisciplinary

Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics

Wei Tao et al.

ADVANCED MATERIALS (2017)

Article Biochemical Research Methods

Control of cerebral ischemia with magnetic nanoparticles

Jie-Min Jia et al.

NATURE METHODS (2017)

Article Cell Biology

Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys

Gregory T. Tietjen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Cell Biology

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

Ken Chen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Multidisciplinary Sciences

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

Minfeng Huo et al.

NATURE COMMUNICATIONS (2017)

Article Engineering, Biomedical

Europium-Doped Cerium Oxide Nanoparticles Limit Reactive Oxygen Species Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury

Ekaterina O. Gubernatorova et al.

ADVANCED HEALTHCARE MATERIALS (2017)

Review Materials Science, Biomaterials

Antioxidant nanomaterials in advanced diagnoses and treatments of ischemia reperfusion injuries

Hamed Amani et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

Article Physiology

Ischemia/Reperfusion

Theodore Kalogeris et al.

COMPREHENSIVE PHYSIOLOGY (2017)

Review Cardiac & Cardiovascular Systems

Anti-inflammatory Nanomedicine for Cardiovascular Disease

Shunsuke Katsuki et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2017)

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

Article Chemistry, Multidisciplinary

Near-Infrared Triggered Release of uPA from Nanospheres for Localized Hyperthermia-Enhanced Thrombolysis

Xiaolei Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Article Chemistry, Multidisciplinary

ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy

Xiaoding Xu et al.

ADVANCED MATERIALS (2017)

Review Chemistry, Multidisciplinary

Platinum nanoparticles in nanobiomedicine

Deborah Pedone et al.

CHEMICAL SOCIETY REVIEWS (2017)

Article Chemistry, Multidisciplinary

Diverse Applications of Nanomedicine

Beatriz Pelaz et al.

ACS NANO (2017)

Review Chemistry, Multidisciplinary

Nanomaterials for In Vivo Imaging

Bryan Ronain Smith et al.

CHEMICAL REVIEWS (2017)

Article Nanoscience & Nanotechnology

Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer

Bingjiang Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Cardiac & Cardiovascular Systems

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

Derek J. Hausenloy et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

Letter Biochemistry & Molecular Biology

Re. NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective

Stefano Toldo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Chemistry, Multidisciplinary

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

Guanying Chen et al.

CHEMICAL REVIEWS (2016)

Review Chemistry, Multidisciplinary

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Mahdi Karimi et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Critical Care Medicine

Inhibition of Plexin C1 Protects Against Hepatic Ischemia-Reperfusion Injury

Klemens Koenig et al.

CRITICAL CARE MEDICINE (2016)

Letter Cardiac & Cardiovascular Systems

Statin and myocardial ischemia-reperfusion injury

Jun Hu et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Letter Cardiac & Cardiovascular Systems

Molecularmechanism of ischemia - Reperfusion injury after myocardial infarction and its possible targeted treatment

Jan Lakota

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Editorial Material Respiratory System

Prevention of pulmonary injury induced by ischemia/reperfusion: many options, no choices

Pedro Caruso et al.

JORNAL BRASILEIRO DE PNEUMOLOGIA (2016)

Article Medicine, Research & Experimental

Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes

Tsuyoshi Inoue et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Editorial Material Cardiac & Cardiovascular Systems

Ischemia reperfusion induced acute lung injury: Using everything and the kitchen

Ashok Muniappan

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2016)

Review Medicine, Research & Experimental

Reactive oxygen species-mediated cardiac-reperfusion injury: Mechanisms and therapies

Fereshte Bagheri et al.

LIFE SCIENCES (2016)

Review Critical Care Medicine

Acute kidney injury following cardiac surgery: current understanding and future directions

Jason B. O'Neal et al.

CRITICAL CARE (2016)

Review Chemistry, Multidisciplinary

Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

Guosong Hong et al.

CHEMICAL REVIEWS (2015)

Letter Cardiac & Cardiovascular Systems

Klotho protein: A potential therapeutic agent during myocardial ischemia and reperfusion

Xiaoya Zhou et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Jose M. Vicencio et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

Borja Ibáñez et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Physiology

Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury

Junjie Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)

Review Chemistry, Multidisciplinary

Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy

Vasudevanpillai Biju

CHEMICAL SOCIETY REVIEWS (2014)

Article Biochemistry & Molecular Biology

Extracellular vesicles: New players in cardiovascular diseases

Abderahim Gaceb et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Article Nanoscience & Nanotechnology

New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI

M. Barbara A. F. Martins et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

Review Gastroenterology & Hepatology

Redox therapeutics in hepatic ischemia reperfusion injury

Rakesh P. Patel et al.

WORLD JOURNAL OF HEPATOLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Passive targeting of lipid-based nanoparticles to mouse cardiac ischemia-reperfusion injury

Tessa Geelen et al.

CONTRAST MEDIA & MOLECULAR IMAGING (2013)

Article Nanoscience & Nanotechnology

An Intrinsic Therapy of Gold Nanoparticles in Focal Cerebral Ischemia-Reperfusion Injury in Rats

Zhengxia Liu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2013)

Review Chemistry, Multidisciplinary

Self-Assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation

Jinjun Shi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2011)

Article Biochemical Research Methods

Metabonomic Study of Chinese Medicine Shuanglong Formula as an Effective Treatment for Myocardial Infarction in Rats

Xiaoping Liang et al.

JOURNAL OF PROTEOME RESEARCH (2011)

Article Cardiac & Cardiovascular Systems

Effect of lung ischemia-reperfusion on oxidative stress parameters of remote tissues

H Esme et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2006)

Review Biochemistry & Molecular Biology

Nitric oxide synthase-independent generation of nitric oxide in muscle ischemia-reperfusion injury

DA Lepore

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2000)