Nationwide observational study of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic

Article Biochemistry & Molecular Biology

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year

J. L. Ward et al.

Summary: The risk of intensive care unit admission among children with COVID-19 or PIMS-TS is influenced by age, ethnicity, and comorbidities, which can guide treatment and prevention strategies.

NATURE MEDICINE (2022)

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Review Critical Care Medicine

Neurological Involvement in COVID-19 and Potential Mechanisms: A Review

Ghazal Aghagoli et al.

Summary: This review synthesizes the literature on the neurological impact of COVID-19, highlighting potential neurologic manifestations and mechanisms, and emphasizes the importance of understanding and mitigating SARS-CoV-2-associated neurologic injury.

NEUROCRITICAL CARE (2021)

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Article Pediatrics

What chances do children have against COVID-19? Is the answer hidden within the thymus?

Hatice Gunes et al.

Summary: The new type of coronavirus, SARS-CoV-2, affects children less frequently and is observed to cause milder symptoms. T cells play a key role in regulating the immune response against the virus, and the loss of T-reg function with age may lead to increased inflammation, as seen in COVID-19. Thymus activity and T lymphocyte function in children are speculated to protect them against the effects of the virus.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Letter Pediatrics

Neurological Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS)

Sagar S. Lad et al.

INDIAN JOURNAL OF PEDIATRICS (2021)

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Review Pediatrics

Multisystem inflammatory syndrome in children related to COVID-19: a systematic review

Levi Hoste et al.

Summary: PIMS-TS/MIS(-C) is a severe, heterogeneous disease with epidemiological enrichment for males, adolescents, and racial and ethnic minorities. Despite its severe presentation, overall short-term outcome is good. The WHO MIS definition is preferred, as it is more precise, while encompassing most cases.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Article Medicine, General & Internal

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19

Leora R. Feldstein et al.

Summary: Comparing the clinical characteristics and outcomes of patients with MIS-C and COVID-19 can help distinguish between the two conditions and improve health outcomes. Patterns of clinical presentation and organ system involvement were identified in this case series, providing valuable information for differentiation of MIS-C and COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children

Naim Ouldali et al.

Summary: Among children with MIS-C, treatment with IVIG and methylprednisolone compared to IVIG alone was associated with a more favorable fever course, reduced risk of needing second-line therapy, hemodynamic support, acute left ventricular dysfunction after initial therapy, and shorter stay in the pediatric intensive care unit. The study interpretation is limited by its observational design.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Pediatrics

Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA a retrospective surveillance study

Joseph Y. Abrams et al.

Summary: Factors such as age, race, clinical symptoms, and laboratory markers were found to be associated with severe outcomes in patients with MIS-C. These findings highlight the importance of early recognition and prompt management for patients with MIS-C.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Article Pediatrics

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study

Camilla E. Lindan et al.

Summary: This study analyzed 38 cases of pediatric neurological diseases related to SARS-CoV-2 infection, identifying a variety of neuroimaging abnormalities. Imaging patterns included postinfectious immune-mediated acute disseminated encephalomyelitis-like changes, myelitis, and neural enhancement. Splenial lesions and myositis were observed predominantly in children with multisystem inflammatory syndrome.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Article Hematology

Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C

Hilary Whitworth et al.

Summary: This study found that age >= 12 years, cancer, presence of a central venous catheter, and MIS-C were significantly associated with thrombosis in children hospitalized with COVID-19 or MIS-C. It is notable that the majority of thrombotic events occurred in patients aged 12 years and older, and nearly one-third of patients experienced thrombosis despite receiving thromboprophylaxis.

BLOOD (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Major left ventricular thrombi in an adolescent with COVID-19-associated inflammatory syndrome

Ondrej Materna et al.

EUROPEAN HEART JOURNAL (2021)

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Article Pediatrics

Pediatric multisystem SARS COV2 with versus without cardiac involvement: a multicenter study from Latin America

Ricardo Pignatelli et al.

Summary: This multinational study on Latin American children with multisystem SARS COV2 found that cardiac involvement was prevalent, and those with cardiac involvement were more likely to require ICU interventions and exhibit respiratory symptoms. Abnormal labs such as elevated troponin, ALT, and thrombocytopenia had high sensitivity and negative predictive value for the need for intensive care interventions.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Review Immunology

SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Vanessa Sancho-Shimizu et al.

Summary: MIS-C, a newly emerging syndrome in children associated with COVID-19, shows heterogeneity resembling KD, possibly triggered by viruses and potentially linked to rare inborn errors of immunity altering the immune response. Discovery of monogenic IEIs underlying MIS-C may pave the way for a new genetic approach to classic KD.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Medicine, General & Internal

Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2

Amanda B. Payne et al.

Summary: In this study, it was found that Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare complication associated with SARS-CoV-2 infection, with higher incidence rates among Black, Hispanic or Latino, and Asian or Pacific Islander individuals. Further research is needed to explore the variations by race/ethnicity and age group.

JAMA NETWORK OPEN (2021)

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Article Health Care Sciences & Services