Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles

Manganese-56 (Mn-56) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of Mn-56 and the radiation emission from excited levels of Fe-56 following Mn-56 beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated Mn-56 in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to Mn-56 is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around Mn-56 dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 mu m, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated Mn-56 dioxide powder.

Automated summary

Manganese-56 (Mn-56) is a significant radioactive isotope generated by neutron activation in the aftermath of atomic bombings. The radiation emissions from Mn-56 and its decay product, Fe-56, include gamma rays, beta particles, Auger electrons, and X-rays. The dispersion of neutron-activated Mn-56 in the air can result in the inhalation of radioactive microparticles into the lungs. The investigation of the spatial distribution of internal doses in biological tissue exposed to Mn-56 is crucial for understanding the potential radiation exposure of lung alveoli and alveolar ducts.