Palladium-catalyzed carbonylative synthesis of indole-3-carboxamides from 2-ethynylanilines and nitroarenes

A palladium-catalyzed carbonylative cyclization of 2-ethynylanilines with nitroarenes has been developed for the rapid synthesis of indole-3-carboxamide skeletons. By using nitroarenes as the nitrogen source and Mo(CO)(6) as the CO surrogate, the reaction proceeded smoothly to furnish various indole-3-carboxamide derivatives in moderate to high yields.

Automated summary

A palladium-catalyzed carbonylative cyclization of 2-ethynylanilines with nitroarenes has been developed for the rapid synthesis of indole-3-carboxamide skeletons. The reaction proceeded smoothly to furnish various indole-3-carboxamide derivatives in moderate to high yields by using nitroarenes as the nitrogen source and Mo(CO)(6) as the CO surrogate.