4.4 Article

Isolation and characterization of human anti-CD20 single-chain variable fragment (scFv) from a Naive human scFv library

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

A phase 2 multicenter study of ublituximab, a novel glycoengineered anti-CD20 monoclonal antibody, in patients with relapsing forms of multiple sclerosis

Edward Fox et al.

Summary: The study demonstrated that Ublituximab is safe and effective in relapsing multiple sclerosis patients, leading to rapid depletion of B-cells and significant reductions in MRI activity and relapses.

MULTIPLE SCLEROSIS JOURNAL (2021)

Article Multidisciplinary Sciences

Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

Hana Storkanova et al.

Summary: According to the study, plasma levels of Hsp90 are increased in patients with systemic sclerosis compared to healthy controls, and are associated with increased inflammatory activity, worsened lung function, and extent of skin involvement in patients with diffuse cutaneous systemic sclerosis. In patients with systemic sclerosis-associated interstitial lung disease treated with cyclophosphamide, baseline Hsp90 levels can predict changes in DLCO over 12 months of therapy.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody

Rodrigo Barbosa de Aguiar et al.

Summary: The study describes a recombinant scFv format for the 3F12E7 mAb that shows specific recognition of FGF2 and inhibition of tumor growth in an experimental model, providing insights for further engineering non-aggregated anti-FGF2 scFv-based tools for therapeutic and research purposes.

SCIENTIFIC REPORTS (2021)

Article Rheumatology

The Type II Anti-CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model

Anthony D. Marinov et al.

Summary: The study found that obinutuzumab (GA101) was more effective than rituximab (RTX) in depleting B cells in diseased MRL/lpr mice, with better treatment outcomes in early disease including reduced glomerulonephritis, lower anti-RNA autoantibody titers, and fewer activated CD4+ T cells. GA101 also prolonged survival in an advanced disease model.

ARTHRITIS & RHEUMATOLOGY (2021)

Article Medicine, General & Internal

Development of a novel, fully human, anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy

Menglong Xu et al.

Summary: A fully human antibody FAP2M21 with potent inhibitory effect on PCSK9 was generated, showing promise as a therapeutic agent for treating hypercholesterolemia and associated cardiovascular diseases.

EBIOMEDICINE (2021)

Article Biotechnology & Applied Microbiology

Solubility assessment of single-chain antibody fragment against epithelial cell adhesion molecule extracellular domain in four Escherichia coli strains

Fatemeh Sadat Javadian et al.

Summary: The study found that among four E. coli strains, BL21(DE3) strain had the highest soluble production level of anti-EpEX-scFv protein, while E. coli SHuffle T7 strain also showed good soluble production capability. BL21(DE3) strain had a higher solubility yield and can be considered a suitable strain for high-level production of anti-EpEX-scFv protein.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Lionel Rouge et al.

SCIENCE (2020)

Article Immunology

Development of ELISA and Lateral Flow Immunoassays for Ochratoxins (OTA and OTB) Detection Based on Monoclonal Antibody

Mohamed Hassan Fadlalla et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Biochemistry & Molecular Biology

Evolution ofEscherichia coliExpression System in Producing Antibody Recombinant Fragments

Annamaria Sandomenico et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Mathematical & Computational Biology

Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models

Noushin Hadadi et al.

NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2020)

Article Multidisciplinary Sciences

Analysis of the B cell receptor repertoire in six immune-mediated diseases

R. J. M. Bashford-Rogers et al.

NATURE (2019)

Meeting Abstract Hematology

CD20 Targeted CAR-T for High-Risk B-Cell Non-Hodgkin Lymphomas

Mazyar Shadman et al.

Review Medicine, Research & Experimental

The applications of anti-CD20 antibodies to treat various B cells disorders

Zahra Payandeh et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Clinical Neurology

B-Cell Therapy for Multiple Sclerosis: Entering an Era

Ariele L. Greenfield et al.

ANNALS OF NEUROLOGY (2018)

Article Endocrinology & Metabolism

The identification of a novel antibody for CD133 using human antibody phage display

Paige M. Glumac et al.

PROSTATE (2018)

Article Biotechnology & Applied Microbiology

Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Shirin Khajeh et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Review Biotechnology & Applied Microbiology

Anti-CD20 monoclonal antibodies: reviewing a revolution

J. M. L. Casan et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

Article Biotechnology & Applied Microbiology

Rituximab (anti-CD20)-modified AZD-2014-encapsulated nanoparticles killing of B lymphoma cells

Xiaolong Tang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Article Biochemical Research Methods

Oligo-clonal nanobodies as an innovative targeting agent for cancer therapy: New biology and novel targeting systems

Shahryar Khoshtinat Nikkhoi et al.

PROTEIN EXPRESSION AND PURIFICATION (2017)

Article Biochemistry & Molecular Biology

Current strategies for protein production and purification enabling membrane protein structural biology

Aditya Pandey et al.

BIOCHEMISTRY AND CELL BIOLOGY (2016)

Letter Medicine, Research & Experimental

Response to: Monoclonal antibodies targeting CD20

Christian Klein et al.

Article Biochemistry & Molecular Biology

GalaxyWEB server for protein structure prediction and refinement

Junsu Ko et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Biochemical Research Methods

Production of disulfide-bonded proteins in Escherichia coli

Mehmet Berkmen

PROTEIN EXPRESSION AND PURIFICATION (2012)

Review Biochemistry & Molecular Biology

Progress in phage display: evolution of the technique and its applications

Tomaz Bratkovic

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Biotechnology & Applied Microbiology

Chromato-panning: an efficient new mode of identifying suitable ligands from phage display libraries

Wim Noppe et al.

BMC BIOTECHNOLOGY (2009)

Article Biotechnology & Applied Microbiology

A compact phage display human scFv library for selection of antibodies to a wide variety of antigens

Potjamas Pansri et al.

BMC BIOTECHNOLOGY (2009)

Article Biochemistry & Molecular Biology

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

Xavier Brochet et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Gastroenterology & Hepatology

Solubility of disulfide-bonded proteins in the cytoplasm of Escherichia coli and its oxidizing mutant

Sheng Xiong et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Article Biochemistry & Molecular Biology

ClusPro: a fully automated algorithm for protein-protein docking

SR Comeau et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biochemistry & Molecular Biology

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

RA Clynes et al.

NATURE MEDICINE (2000)