期刊
JOURNAL OF IMMUNOLOGY
卷 209, 期 2, 页码 217-225出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2200105
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资金
- European Research Council [885435]
- Ligue Contre le Cancer
- Conseil Region Pays de la Loire
- Institut National de la Sante et de la Recherche Medicale Centre National de la Recherche Scientifique
- Institut Curie
- Agence Nationale de la Recherche (Jeunes Chercheuses et Jeunes Chercheurs MAIT, Labex Dendritic Cell Biology)
- Agence Nationale de la Recherche (MAIT-Repair, Labex Immunotherapy Graft Oncology, HemaNext)
- European Research Council (ERC) [885435] Funding Source: European Research Council (ERC)
Innate-like T cells display characteristics of both ILCs and mainstream alpha beta T cells, and are probably present in all vertebrates. Their main characteristics are better known in amphibians and mammals. These cells include both gamma delta and alpha beta T cells, and each subset fulfills nonredundant roles related to their Ag specificity.
Innate-like T cells display characteristics of both innate lymphoid cells (ILCs) and mainstream alpha beta T cells, leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that although innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both gamma delta and alpha beta T cells. In mammals, gamma delta TCRs likely coevolved with molecules of the butyrophilin family they interact with, whereas the semi-invariant TCRs of iNKT and mucosal-associated invariant T cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the Ag recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each one fulfills nonredundant roles related to their Ag specificity.
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