期刊
CURRENT OPINION IN CHEMICAL ENGINEERING
卷 14, 期 -, 页码 103-109出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coche.2016.09.003
关键词
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资金
- California NanoSystems Institute (CNSI)
- University of California
- Santa Barbara
- University of California, Office of the President
- Office of Science (BER), U.S. Department of Energy [DE-SC0010352]
- Institute for Collaborative Biotechnologies [W911NF-09-0001]
- National Science Foundation [MCB-1553721]
- National Science Foundation Graduate Research Fellowship Program [DGE 1144085]
- U.S. Department of Energy (DOE) [DE-SC0010352] Funding Source: U.S. Department of Energy (DOE)
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1553721] Funding Source: National Science Foundation
Microbial bioprocessing has evolved from the use of undefined natural consortia to the construction of synthetic communities tailored to specific processes and bioproducts. This evolution is enabled by recent advances in biotechnology, including cultivation of non-model microbes, metabolic engineering, bioinformatics, and numerical modeling. Equipped with these powerful tools, engineers have designed co-cultures and consortia with an expanded set of capabilities, mainly via ` bottom-up' approaches that tether isolates together in culture. Here, we present a brief review of the opportunities, challenges, and recent developments in consortia-based bioprocessing with a focus on lignocellulosic biomass conversion. With improved understanding of microbial community composition and function, we further present a vision to harness defined consortia down-selected from nature via ` top down' approaches.
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