期刊
CURRENT OPINION IN CHEMICAL ENGINEERING
卷 11, 期 -, 页码 77-84出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coche.2016.01.011
关键词
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资金
- National Institutes of Health [R01 EB017753]
- Physical Sciences Oncology Center at the University of Pennsylvania, National Institutes of Health [U54 CA193417]
Tissue stiffness is tightly controlled under normal conditions, but changes with disease. In cancer, tumors often tend to be stiffer than the surrounding uninvolved tissue, yet the cells themselves soften. Within the past decade, and particularly in the last few years, there is increasing evidence that the stiffness of the extracellular matrix modulates cancer and stromal cell mechanics and function, influencing such disease hallmarks as angiogenesis, migration, and metastasis. This review briefly summarizes recent studies that investigate how cancer cells and fibrosis-relevant stromal cells respond to ECM stiffness, the possible sensing appendages and signaling mechanisms involved, and the emergence of novel substrates - including substrates with scar-like fractal heterogeneity - that mimic the in vivo mechanical environment of the cancer cell.
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