期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 19, 页码 5197-5204出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01001a
关键词
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资金
- Fundamental Research Funds for the Central Universities [DUT21LAB134]
A stereoselective (3 + 2) annulation process between 4-bromo pyrazolones and benzofuran-derived azadienes was developed, leading to the synthesis of novel pyrazole fused spiroketals. The process exhibits simple operation, mild conditions, and fast reaction rate. The asymmetric (3 + 2) annulation reaction was explored, along with the identification of an optimal catalytic system.
A stereoselective (3 + 2) annulation process between 4-bromo pyrazolones and benzofuran-derived azadienes was developed. A series of novel pyrazole fused spiroketals were synthesized in the presence of a base. The process has the salient features of simple operation, mild conditions, and fast reaction rate. The asymmetric (3 + 2) annulation reaction was initially explored, and an optimal catalytic system was obtained. The applicability of a few substrates was investigated, highlighting the possibility of asymmetric catalytic synthesis of chiral pyrazole fused spiroketals.
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