期刊
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
卷 14, 期 2, 页码 168-176出版社
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
DOI: 10.9758/cpn.2016.14.2.168
关键词
Autonomic nervous system; Depression; Heart-rate-variability-biofeedback; Heroin
资金
- National Science Council, Taiwan (ROC) [NSC101-2314-B-037-057-MY3]
Objective: Low heart rate variability (HRV) has been confirmed in heroin users, but the effects of heart-rate-variability-biofeedback in heroin users remain unknown, This study examined (1) correlations between depression and HRV indices; (2) group differences in HRV indices among a heroin-user group, a group with major depressive disorder but no heroin use, and healthy controls; and (3) the effects of heart-rate-variability-biofeedback on depressive symptoms, HRV indices, and respiratory rates within the heroin group. Methods: All participants completed a depression questionnaire and underwent electrocardiogram measurements, and group differences in baseline HRV indices were examined. The heroin group underwent electrocardiogram and respiration rate measurements at baseline, during a depressive condition, and during a happiness condition, before and after which they took part in the heart-rate-variability-biofeedback program, The effects of heart-rate-variability-biofeedback on depressive symptoms, HRV indices, and respiration rates were examined. Results: There was a negative correlation between depression and high frequency of HRV, and a positive correlation between depression and low frequency to high frequency ratio of HRV. The heroin group had a lower overall and high frequency of HRV, and a higher low frequency/high frequency ratio than healthy controls. The heart-rate-variability-biofeedback intervention increased HRV indices and decreased respiratory rates from pre-intervention to post-intervention. Conclusion: Reduced parasympathetic and increased sympathetic activations were found in heroin users. Heart-rate-variability biofeedback was an effective non-pharmacological intervention to restore autonomic balance,
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